CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006072
UniProt Accession
Genbank Protein ID
 D10715 
Genbank Nucleotide ID
Protein Name
 Developmentally-regulated GTP-binding protein 1 
Protein Synonyms/Alias
 DRG-1; Neural precursor cell expressed developmentally down-regulated protein 3; NEDD-3 
Gene Name
 Drg1 
Gene Synonyms/Alias
 Drg; Nedd-3; Nedd3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
7*MSGTLAKIAEIEAEubiquitination[1]
46RRELITPKGGGGGGPubiquitination[1]
112VIRYKGAKIQLLDLPubiquitination[1]
126PGIIEGAKDGKGRGRubiquitination[1]
159LKPLGHKKIIENELEubiquitination[1]
175FGIRLNSKPPNIGFKubiquitination[1]
213KSILAEYKIHNADVTubiquitination[1]
290EKIWDYLKLVRIYTKubiquitination[1]
299VRIYTKPKGQLPDYTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest. 
Sequence Annotation
 DOMAIN 76 169 G.
 NP_BIND 71 78 GTP (By similarity).
 NP_BIND 117 121 GTP (By similarity).
 NP_BIND 248 251 GTP (By similarity).
 REGION 1 16 Required for interaction with STK16 (By
 MOD_RES 100 100 Phosphothreonine; by STK16 (By  
Keyword
 Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 367 AA 
Protein Sequence
MSGTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA 60
KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG 120
IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG 180
FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY 240
IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG 300
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED 360
VIQIVKK 367 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005844; C:polysome; IEA:Compara.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW. 
Interpro
 IPR006074; GTP1-OBG_CS.
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR004095; TGS.
 IPR012676; TGS-like. 
Pfam
 PF01926; MMR_HSR1
 PF02824; TGS 
SMART
  
PROSITE
 PS00905; GTP1_OBG 
PRINTS
 PR00326; GTP1OBG.