CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021725
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Clpx 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
127VSSTRFVKCEKCHHFacetylation[1]
149DSKKSIIKEPESAAEacetylation[1]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of clpP (By similarity). 
Sequence Annotation
 ZN_FING 106 131 C4-type.
 NP_BIND 294 301 ATP.
 MOD_RES 438 438 N6-acetyllysine (By similarity).
 MOD_RES 618 618 Phosphoserine (By similarity).  
Keyword
 Acetylation; ATP-binding; Chaperone; Complete proteome; Metal-binding; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 634 AA 
Protein Sequence
MSSCGACTCG AAAARLLTTS LTSAQRGISC GRIHVPVLGR LGTTLDAQAL RRAPLRTFSE 60
TPAYFASKDG ANKDGSGDGN KKSVTEGSSK KSGSGNSGKG GNQLRCPKCG DLCTHVETFV 120
SSTRFVKCEK CHHFFVVLSE ADSKKSIIKE PESAAEAVKL AFQQKPPPPP KKIYNYLDKY 180
VVGQSFAKKV LSVAVYNHYK RIYNNIPANL RQQAEAEKQT SLTPRELEIR RREDEYRFTK 240
LLQIAGISPH GNALGASMQQ QVNQQMPQEK RGGEVLDSSQ DDIKLEKSNI LLLGPTGSGK 300
TLLAQTLAKC LDVPFAICDC TTLTQAGYVG EDIESVIAKL LQDANYNVEK AQQGIVFLDE 360
VDKIGSVPGI HQLRDVGGEG VQQGLLKLLE GTIVNVPEKN SRKLRGETVQ VDTTNVLFVA 420
SGAFNGLDRI ISRRKNEKYL GFGTPSNLGK GRRAAAAADL ANRSGESNTH QDIEEKDRLL 480
RHVEARDLIE FGMIPEFVGR LPVVVPLHSL DEKTLVQILT EPRNAVIPQY QALFSMDKCE 540
LNVTEDALKA IARLALERKT GARGLRSIME KLLLEPMFEV PNSDIVCVEV DKEVVEGKKE 600
PGYIRAPSKE SSEEEYDSGV EEDGWPRQAD AANS 634 
Gene Ontology
 GO:0009841; C:mitochondrial endopeptidase Clp complex; IEA:Compara.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0042645; C:mitochondrial nucleoid; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005524; F:ATP binding; IDA:MGI.
 GO:0004176; F:ATP-dependent peptidase activity; IEA:Compara.
 GO:0016887; F:ATPase activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016504; F:peptidase activator activity; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:Compara. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013093; ATPase_AAA-2.
 IPR019489; Clp_ATPase_C.
 IPR004487; Clp_protease_ATP-bd_su_ClpX.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07724; AAA_2
 PF10431; ClpB_D2-small 
SMART
 SM00382; AAA
 SM01086; ClpB_D2-small 
PROSITE
  
PRINTS