UniProt Accession

 NUD10_MOUSE; P0C027; Q8BKF4 

Genbank Protein ID

 BC055771 

Genbank Nucleotide ID

 AAH55771.1 

Protein Name

 Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 

Protein Synonyms/Alias

 DIPP-3-alpha; DIPP3-alpha; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-alpha; Diadenosine hexaphosphate hydrolase (AMP-forming); Nucleoside diphosphate-linked moiety X motif 10; Nudix motif 10 

Gene Name

 Nudt10 

Gene Synonyms/Alias

 Dipp3a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
133	IKVLQCHKPVHAEYL	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear. 

Sequence Annotation

 DOMAIN 17 144 Nudix hydrolase.
 REGION 17 19 Substrate binding (By similarity).
 REGION 89 91 Substrate binding (By similarity).
 MOTIF 50 71 Nudix box.
 ACT_SITE 68 68 Proton acceptor (By similarity).
 METAL 49 49 Magnesium 1; via carbonyl oxygen (By
 METAL 65 65 Magnesium 2 (By similarity).
 METAL 65 65 Magnesium 3 (By similarity).
 METAL 69 69 Magnesium 1 (By similarity).
 BINDING 9 9 Substrate (By similarity).
 BINDING 40 40 Substrate (By similarity).
 MOD_RES 148 148 Phosphoserine (By similarity).
 MOD_RES 150 150 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 164 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008486; F:diphosphoinositol-polyphosphate diphosphatase activity; IEA:EC.
 GO:0052840; F:inositol diphosphate tetrakisphosphate diphosphatase activity; IEA:EC.
 GO:0052846; F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity; IEA:EC.
 GO:0052847; F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; IEA:EC.
 GO:0052843; F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity; IEA:EC.
 GO:0052848; F:inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity; IEA:EC.
 GO:0052844; F:inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity; IEA:EC.
 GO:0052845; F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR020476; Nudix_hydrolase.
 IPR020084; NUDIX_hydrolase_CS.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS

 PR00502; NUDIXFAMILY.