| Tag | Content |
|---|
| CPLM ID | CPLM-012271 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ARF GTPase-activating protein GIT2 |
Protein Synonyms/Alias | ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2 |
Gene Name | GIT2 |
Gene Synonyms/Alias | KIAA0148 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 131 | DDDSVTAKDLSKQLH | ubiquitination | [1] | | 135 | VTAKDLSKQLHSSVR | ubiquitination | [1] | | 366 | GSSLSGSKDNVELIL | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | GTPase-activating protein for the ADP ribosylation factor family. |
Sequence Annotation | DOMAIN 1 124 Arf-GAP.
REPEAT 132 161 ANK 1.
REPEAT 166 195 ANK 2.
REPEAT 199 228 ANK 3.
ZN_FING 11 34 C4-type.
MOD_RES 394 394 Phosphoserine.
MOD_RES 397 397 Phosphoserine.
MOD_RES 401 401 Phosphothreonine (By similarity).
MOD_RES 415 415 Phosphoserine.
MOD_RES 418 418 Phosphoserine.
MOD_RES 421 421 Phosphoserine.
MOD_RES 484 484 Phosphotyrosine.
MOD_RES 559 559 Phosphoserine.
MOD_RES 586 586 Phosphoserine (By similarity).
MOD_RES 614 614 Phosphoserine. |
Keyword | Alternative splicing; ANK repeat; Complete proteome; GTPase activation; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 759 AA |
Protein Sequence | MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH LKHTPWPPTL 60
LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH PNKAEFIRAK YQMLAFVHRL 120
PCRDDDSVTA KDLSKQLHSS VRTGNLETCL RLLSLGAQAN FFHPEKGNTP LHVASKAGQI 180
LQAELLAVYG ADPGTQDSSG KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD 240
HKNGQHFIIP QMADSSLDLS ELAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLA 300
TQNHSALVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL SDAKRRQQGS 360
SLSGSKDNVE LILKTINNQH SVESQDNDQP DYDSVASDED TDLETTASKT NRQKSLDSDL 420
SDGPVTVQEF MEVKNALVAS EAKIQQLMKV NNNLSDELRI MQKKLQTLQS ENSNLRKQAT 480
TNVYQVQTGS EYTDTSNHSS LKRRPSARGS RPMSMYETGS GQKPYLPMGE ASRPEESRMR 540
LQPFPAHIGR SALVTSSSSL PSFPSTLSWS RDESARRASR LEKQNSTPES DYDNTPNDME 600
PDGMGSSRKG RQRSMVWPGD GLVPDTAEPH VAPSPTLPST EDVIRKTEQI TKNIQELLRA 660
AQENKHDSYI PCSERIHVAV TEMAALFPKK PKSDMVRTSL RLLTSSAYRL QSECKKTLPG 720
DPGSPTDVQL VTQQVIQCAY DIAKAAKQLV TITTKENNN 759 |
Gene Ontology | GO:0005654; C:nucleoplasm; IDA:UniProtKB. GO:0008060; F:ARF GTPase activator activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:ProtInc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |