UniProt Accession

 PLBL2_HUMAN; Q8NHP8 

Genbank Protein ID

 AC010178; BC030618 

Genbank Nucleotide ID

 AAH30618.1 

Protein Name

 Putative phospholipase B-like 2 

Protein Synonyms/Alias

 76 kDa protein; p76; LAMA-like protein 2; Lamina ancestor homolog 2; Phospholipase B domain-containing protein 2; Putative phospholipase B-like 2 32 kDa form; Putative phospholipase B-like 2 45 kDa form 

Gene Name

 PLBD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
190	RLTLLQLKGLEDSYE	ubiquitination	[1, 2, 3]
367	ATWADIFKRFNSGTY	ubiquitination	[1]
384	QWMIVDYKAFIPGGP	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Putative phospholipase (By similarity). 

Sequence Annotation

 CARBOHYD 88 88 N-linked (GlcNAc...).
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 231 231 N-linked (GlcNAc...).
 CARBOHYD 436 436 N-linked (GlcNAc...).
 CARBOHYD 465 465 N-linked (GlcNAc...).
 CARBOHYD 515 515 N-linked (GlcNAc...).
 DISULFID 142 152 By similarity.
 DISULFID 492 495 By similarity.  

Keyword

 Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Hydrolase; Lipid degradation; Lipid metabolism; Lysosome; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 589 AA 

Protein Sequence

Gene Ontology

 GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR007000; PLipase_B-like. 

Pfam

 PF04916; Phospholip_B 

SMART

  

PROSITE

  

PRINTS