CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018729
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SMG7 
Protein Synonyms/Alias
 EST1-like protein C; SMG-7 homolog; hSMG-7 
Gene Name
 SMG7 
Gene Synonyms/Alias
 C1orf16; EST1C; KIAA0250 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54DLEYALDKKVEQDLWubiquitination[1]
66DLWNHAFKNQITTLQubiquitination[1, 2]
77TTLQGQAKNRANPNRubiquitination[1]
817LGKIMPVKQPYYLQTubiquitination[1, 2]
847MQQQPLEKKMKPFPMubiquitination[1]
956MFNEVYGKNLTSSSKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 
Sequence Annotation
 REPEAT 152 185 TPR 1.
 REPEAT 187 219 TPR 2.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 520 520 Phosphoserine.
 MOD_RES 781 781 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1137 AA 
Protein Sequence
MSLQSAQYLR QAEVLKADMT DSKLGPAEVW TSRQALQDLY QKMLVTDLEY ALDKKVEQDL 60
WNHAFKNQIT TLQGQAKNRA NPNRSEVQAN LSLFLEAASG FYTQLLQELC TVFNVDLPCR 120
VKSSQLGIIS NKQTHTSAIV KPQSSSCSYI CQHCLVHLGD IARYRNQTSQ AESYYRHAAQ 180
LVPSNGQPYN QLAILASSKG DHLTTIFYYC RSIAVKFPFP AASTNLQKAL SKALESRDEV 240
KTKWGVSDFI KAFIKFHGHV YLSKSLEKLS PLREKLEEQF KRLLFQKAFN SQQLVHVTVI 300
NLFQLHHLRD FSNETEQHTY SQDEQLCWTQ LLALFMSFLG ILCKCPLQNE SQEESYNAYP 360
LPAVKVSMDW LRLRPRVFQE AVVDERQYIW PWLISLLNSF HPHEEDLSSI SATPLPEEFE 420
LQGFLALRPS FRNLDFSKGH QGITGDKEGQ QRRIRQQRLI SIGKWIADNQ PRLIQCENEV 480
GKLLFITEIP ELILEDPSEA KENLILQETS VIESLAADGS PGLKSVLSTS RNLSNNCDTG 540
EKPVVTFKEN IKTREVNRDQ GRSFPPKEVR RDYSKGITVT KNDGKKDNNK RKTETKKCTL 600
EKLQETGKQN VAVQVKSQTE LRKTPVSEAR KTPVTQTPTQ ASNSQFIPIH HPGAFPPLPS 660
RPGFPPPTYV IPPPVAFSMG SGYTFPAGVS VPGTFLQPTA HSPAGNQVQA GKQSHIPYSQ 720
QRPSGPGPMN QGPQQSQPPS QQPLTSLPAQ PTAQSTSQLQ VQALTQQQQS PTKAVPALGK 780
SPPHHSGFQQ YQQADASKQL WNPPQVQGPL GKIMPVKQPY YLQTQDPIKL FEPSLQPPVM 840
QQQPLEKKMK PFPMEPYNHN PSEVKVPEFY WDSSYSMADN RSVMAQQANI DRRGKRSPGV 900
FRPEQDPVPR MPFEKSLLEK PSELMSHSSS FLSLTGFSLN QERYPNNSMF NEVYGKNLTS 960
SSKAELSPSM APQETSLYSL FEGTPWSPSL PASSDHSTPA SQSPHSSNPS SLPSSPPTHN 1020
HNSVPFSNFG PIGTPDNRDR RTADRWKTDK PAMGGFGIDY LSATSSSESS WHQASTPSGT 1080
WTGHGPSMED SSAVLMESLK SIWSSSMMHP GPSALEQLLM QQKQKQQRGQ GTMNPPH 1137 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HGNC.
 GO:0051721; F:protein phosphatase 2A binding; IDA:HGNC.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0006406; P:mRNA export from nucleus; TAS:HGNC.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:HGNC.
 GO:0035303; P:regulation of dephosphorylation; TAS:HGNC. 
Interpro
 IPR018834; DNA/RNA-bd_Est1-type.
 IPR019458; EST1.
 IPR011990; TPR-like_helical. 
Pfam
 PF10374; EST1
 PF10373; EST1_DNA_bind 
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS