CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030381
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interleukin-1 receptor-associated kinase 1 (Predicted) 
Protein Synonyms/Alias
 Irak1 protein; Protein Irak1 
Gene Name
 Irak1 
Gene Synonyms/Alias
 Irak1_predicted; rCG_43846 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
397YLPEEYIKTGRLAVDubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 710 AA 
Protein Sequence
MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 60
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPASVLP PSTGAPRPSS 120
ISAGSETEDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLSDSLGPP LQSSAPSSIK 180
PSPESPVSGL QRARPSPFCW PFCEISQGTC NFSEELRIGE GGFGCVYRAV MRNTTYAVKR 240
LKEEADLEWT VVKQSFLTEV EQLSRFRHPN IVDFAGYCAE SGFYCLVYGF LPNGSLEDQL 300
HLQTQACSPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLMPKLGDFG 360
LARFSRFAGA NPSQSSTVAR TCTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVILETLAG 420
QRAVRTQGAK TKYLKDLIED EAEEVGVTLK STQPTLWMGV ATDAWTAPIA AQIYKKHLDS 480
RPGPCPPQLG LALAQLACCC MHRRAKKRPP MTQVYKRLEG LQAVPPWKLE VAGHGSPSPQ 540
ENSYMSTTGS AQSGDEPWQP LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH 600
LTPDSHPSPV SFREASCTQG GTTRESSLRS GPGFQPTTME GSSMGSSSLL SSEPPQIIIN 660
PARQKMVQKL ALYEEGVLDS LQLLSSGFFP GLDLEPEKRK RPEESDEFQS 710 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004672; F:protein kinase activity; IDA:RGD.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:Compara.
 GO:0071456; P:cellular response to hypoxia; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
 GO:0019221; P:cytokine-mediated signaling pathway; IMP:RGD.
 GO:0070498; P:interleukin-1-mediated signaling pathway; IEA:Compara.
 GO:0007254; P:JNK cascade; IMP:RGD.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0051259; P:protein oligomerization; IEA:Compara.
 GO:0001959; P:regulation of cytokine-mediated signaling pathway; IEA:Compara.
 GO:0032494; P:response to peptidoglycan; IEA:Compara.
 GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:Compara.
 GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Compara. 
Interpro
 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00531; Death
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS