UniProt Accession

 COX5B_HUMAN; P10606; Q53YB7; Q96J18; Q99610 

Genbank Protein ID

 M19961; M59250; BT006742; AC017099; BC006229; U41284 

Genbank Nucleotide ID

 AAA52061.1; AAA52060.1; AAP35388.1; AAY24279.1; AAH06229.1; AAB19185.1 

Protein Name

 Cytochrome c oxidase subunit 5B, mitochondrial 

Protein Synonyms/Alias

 Cytochrome c oxidase polypeptide Vb 

Gene Name

 COX5B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
57	EIMLAAKKGLDPYNV	ubiquitination	[1, 2, 3]
68	PYNVLAPKGASGTRE	ubiquitination	[1, 3]
86	LVPSISNKRIVGCIC	ubiquitination	[1, 3]
121	PRCGAHYKLVPQQLA	acetylation	[4]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. 

Sequence Annotation

 METAL 91 91 Zinc (By similarity).
 METAL 93 93 Zinc (By similarity).
 METAL 113 113 Zinc (By similarity).
 METAL 116 116 Zinc (By similarity).  

Keyword

 Complete proteome; Direct protein sequencing; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transit peptide; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 129 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0007585; P:respiratory gaseous exchange; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002124; Cyt_c_oxidase_su5b.
 IPR020893; Cyt_c_oxidase_su5b_Zn_BS. 

Pfam

 PF01215; COX5B 

SMART

  

PROSITE

 PS00848; COX5B_1
 PS51359; COX5B_2 

PRINTS