CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016340
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Copine-8 
Protein Synonyms/Alias
 Copine VIII 
Gene Name
 CPNE8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58YVQGVGNKEWREFGRubiquitination[1]
177DKKDFFGKSDPFLVFubiquitination[2]
405EAYYRSLKSVQLYGPubiquitination[2, 3, 4]
Reference
 [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity). 
Sequence Annotation
 DOMAIN 10 117 C2 1.
 DOMAIN 144 249 C2 2.
 DOMAIN 309 510 VWFA.
 MOD_RES 260 260 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 564 AA 
Protein Sequence
MDSRYNSTAG IGDLNQLSAA IPATRVEVSV SCRNLLDRDT FSKSDPICVL YVQGVGNKEW 60
REFGRTEVID NTLNPDFVRK FILDYFFEER ENLRFDLYDV DSKSPNLSKH DFLGQVFCTL 120
GEIVGSQGSR LEKPIVGIPG KKCGTIILTA EELNCCRDAV LMQFCANKLD KKDFFGKSDP 180
FLVFYRSNED GSFTICHKTE VVKNTLNPVW QAFKISVRAL CNGDYDRTIK VEVYDWDRDG 240
SHDFIGEFTT SYRELSRGQS QFNVYEVVNP KKKGKKKKYT NSGTVTLLSF LVETEVSFLD 300
YIKGGTQINF TVAIDFTASN GNPAQPTSLH YMNPYQLNAY GMALKAVGEI VQDYDSDKMF 360
PALGFGAKLP PDGRISHEFA LNGNPQNPYC DGIEGVMEAY YRSLKSVQLY GPTNFAPVIN 420
HVARYASSVK DGSQYFVLLI VTDGVISDMA QTKESIVNAS KLPMSIIIVG VGPAEFDAMV 480
ELDGDDVRVS SRGKYAERDI VQFVPFRDYI DRSGNHILSM ARLAKDVLAE IPEQFLSYMR 540
ARGIKPSPAP PPYTPPTHVL QTQI 564 
Gene Ontology
  
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010734; Copine.
 IPR002035; VWF_A. 
Pfam
 PF00168; C2
 PF07002; Copine 
SMART
 SM00239; C2
 SM00327; VWA 
PROSITE
 PS50004; C2
 PS50234; VWFA 
PRINTS