UniProt Accession

 CLIC1_RAT; Q6MG61 

Genbank Protein ID

 BX883045; CH474121; BC099823 

Genbank Nucleotide ID

 CAE83985.1; EDL83493.1; AAH99823.1 

Protein Name

 Chloride intracellular channel protein 1 

Protein Synonyms/Alias

  

Gene Name

 Clic1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
119	AKFSAYIKNSNPALN	acetylation	[1]
131	ALNDNLEKGLLKALK	acetylation	[1]
135	NLEKGLLKALKVLDN	acetylation	[1]
138	KGLLKALKVLDNYLT	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). 

Sequence Annotation

 DOMAIN 93 233 GST C-terminal.
 REGION 2 90 Required for insertion into the membrane
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 13 13 N6-acetyllysine (By similarity).
 MOD_RES 119 119 N6-acetyllysine (By similarity).
 MOD_RES 131 131 N6-acetyllysine (By similarity).
 MOD_RES 135 135 N6-acetyllysine (By similarity).
 MOD_RES 233 233 Phosphotyrosine (By similarity).
 DISULFID 24 59 By similarity.  

Keyword

 Acetylation; Cell membrane; Chloride; Chloride channel; Complete proteome; Cytoplasm; Direct protein sequencing; Disulfide bond; Ion channel; Ion transport; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005635; C:nuclear envelope; TAS:RGD.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005247; F:voltage-gated chloride channel activity; TAS:RGD.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0051881; P:regulation of mitochondrial membrane potential; IEA:Compara. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR002946; Int_Cl_channel.
 IPR012336; Thioredoxin-like_fold. 

Pfam

  

SMART

  

PROSITE

 PS50405; GST_CTER 

PRINTS

 PR01263; INTCLCHANNEL.