CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036213
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-binding and coiled-coil domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 CALCOCO2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
141ETELLQLKEQNQKMSubiquitination[1]
153KMSSENEKMGIRVDQubiquitination[1]
170AQLSTQEKEMEKLVQubiquitination[2]
227NETTAMKKQQELMDEubiquitination[1, 2, 3, 4, 5]
240DENFDLSKRLSENEIubiquitination[1, 2, 4, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 259 AA 
Protein Sequence
MWVTLPIDLN NKSAKQQEVQ FKAYYLPKDD EYYQFCYVDE DGVVRGASIP FQFRPENEED 60
ILVVTTQGEV EEIEQHNKEL CKENQELKDS CISLQKQNSD MQAELQKKQE ELETLQSINK 120
KLELKVKEQK DYWETELLQL KEQNQKMSSE NEKMGIRVDQ LQAQLSTQEK EMEKLVQGDQ 180
DKTEQLEQLK KENDHLFLSL TEQRKDQKKL EQTVEQMKQN ETTAMKKQQE LMDENFDLSK 240
RLSENEIICN ALQRQKERL 259 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS