CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016929
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-1 
Protein Synonyms/Alias
 Actin I 
Gene Name
 PFL2215w 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
69KRGILTLKYPIEHGIacetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility. 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 376 AA 
Protein Sequence
MGEEDVQALV VDNGSGNVKA GVAGDDAPRS VFPSIVGRPK NPGIMVGMEE KDAFVGDEAQ 60
TKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRAAPE EHPVLLTEAP LNPKGNRERM 120
TQIMFESFNV PAMYVAIQAV LSLYSSGRTT GIVLDSGDGV SHTVPIYEGY ALPHAIMRLD 180
LAGRDLTEYL MKILHERGYG FSTSAEKEIV RDIKEKLCYI ALNFDEEMKT SEQSSDIEKS 240
YELPDGNIIT VGNERFRCPE ALFQPSFLGK EAAGIHTTTF NSIKKCDVDI RKDLYGNIVL 300
SGGTTMYEGI GERLTRDITT LAPSTMKIKV VAPPERKYSV WIGGSILSSL STFQQMWITK 360
EEYDESGPSI VHRKCF 376 
Gene Ontology
 GO:0005884; C:actin filament; ISS:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0005200; F:structural constituent of cytoskeleton; ISS:UniProtKB.
 GO:0070359; P:actin polymerization-dependent cell motility involved in migration of symbiont in host; ISS:UniProtKB.
 GO:0007010; P:cytoskeleton organization; ISS:GeneDB_Pfalciparum. 
Interpro
 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 
PRINTS
 PR00190; ACTIN.