CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016989
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prolyl 3-hydroxylase 2 
Protein Synonyms/Alias
 Leprecan-like protein 1; Myxoid liposarcoma-associated protein 4 
Gene Name
 LEPREL1 
Gene Synonyms/Alias
 MLAT4; P3H2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
160YLQRAYIKLNQLEKAubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Shows prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types II, IV and V (By similarity). 
Sequence Annotation
 REPEAT 44 77 TPR 1.
 REPEAT 148 181 TPR 2.
 REPEAT 210 243 TPR 3.
 REPEAT 306 339 TPR 4.
 DOMAIN 557 671 Fe2OG dioxygenase.
 MOTIF 705 708 Prevents secretion from ER (Potential).
 ACT_SITE 662 662 By similarity.
 METAL 580 580 Iron.
 METAL 582 582 Iron.
 METAL 652 652 Iron.
 CARBOHYD 449 449 N-linked (GlcNAc...) (Potential).
 CARBOHYD 549 549 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Dioxygenase; Disease mutation; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Iron; Metal-binding; Oxidoreductase; Polymorphism; Reference proteome; Repeat; Signal; TPR repeat; Vitamin C. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 708 AA 
Protein Sequence
MRERIWAPPL LLLLPLLLPP PLWGGPPDSP RRELELEPGP LQPFDLLYAS GAAAYYSGDY 60
ERAVRDLEAA LRSHRRLREI RTRCARHCAA RHPLPPPPPG EGPGAELPLF RSLLGRARCY 120
RSCETQRLGG PASRHRVSED VRSDFQRRVP YNYLQRAYIK LNQLEKAVEA AHTFFVANPE 180
HMEMQQNIEN YRATAGVEAL QLVDREAKPH MESYNAGVKH YEADDFEMAI RHFEQALREY 240
FVEDTECRTL CEGPQRFEEY EYLGYKAGLY EAIADHYMQV LVCQHECVRE LATRPGRLSP 300
IENFLPLHYD YLQFAYYRVG EYVKALECAK AYLLCHPDDE DVLDNVDYYE SLLDDSIDPA 360
SIEAREDLTM FVKRHKLESE LIKSAAEGLG FSYTEPNYWI RYGGRQDENR VPSGVNVEGA 420
EVHGFSMGKK LSPKIDRDLR EGGPLLYENI TFVYNSEQLN GTQRVLLDNV LSEEQCRELH 480
SVASGIMLVG DGYRGKTSPH TPNEKFEGAT VLKALKSGYE GRVPLKSARL FYDISEKARR 540
IVESYFMLNS TLYFSYTHMV CRTALSGQQD RRNDLSHPIH ADNCLLDPEA NECWKEPPAY 600
TFRDYSALLY MNDDFEGGEF IFTEMDAKTV TASIKPKCGR MISFSSGGEN PHGVKAVTKG 660
KRCAVALWFT LDPLYRELER IQADEVIAIL DQEQQGKHEL NINPKDEL 708 
Gene Ontology
 GO:0005604; C:basement membrane; ISS:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW.
 GO:0019797; F:procollagen-proline 3-dioxygenase activity; IDA:UniProtKB.
 GO:0032963; P:collagen metabolic process; IDA:UniProtKB.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.
 GO:0019511; P:peptidyl-proline hydroxylation; IDA:UniProtKB. 
Interpro
 IPR005123; Oxoglu/Fe-dep_dioxygenase.
 IPR006620; Pro_4_hyd_alph.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2. 
Pfam
 PF13640; 2OG-FeII_Oxy_3
 PF07719; TPR_2 
SMART
 SM00702; P4Hc 
PROSITE
 PS00014; ER_TARGET
 PS51471; FE2OG_OXY
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS