UniProt Accession

 ANXA1_RAT; P07150; Q64664 

Genbank Protein ID

 Y00446; M19967; S57478; S57447; S57450; S57455; S57459; S57463; S57466; S57468; S57470; S57472; S57474; S57476; BC061710 

Genbank Nucleotide ID

 CAA68500.1; AAA40861.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAB19866.1; AAH61710.1 

Protein Name

 Annexin A1 

Protein Synonyms/Alias

 Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I; Phospholipase A2 inhibitory protein; p35 

Gene Name

 Anxa1 

Gene Synonyms/Alias

 Anx1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
16	KQACYIEKQEQEYVQ	acetylation	[1]
71	TIIDILTKRTNAQRQ	acetylation	[1]
90	AYLQETGKPLDETLK	acetylation	[1]
97	KPLDETLKKALTGHL	acetylation	[1]
128	DELRAAMKGLGTDED	acetylation	[1]
161	RVYREELKRDLAKDI	acetylation	[1]
166	ELKRDLAKDITSDTS	acetylation	[1]
185	NALLALAKGDRCEDM	acetylation	[1]
242	KVFQNYRKYSQHDMN	acetylation	[1]
257	KALDLELKGDIEKCL	acetylation	[1]
312	EIDMNEIKVFYQKKY	acetylation	[1]
317	EIKVFYQKKYGIPLC	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. 

Sequence Annotation

 REPEAT 51 111 Annexin 1.
 REPEAT 123 183 Annexin 2.
 REPEAT 207 267 Annexin 3.
 REPEAT 282 342 Annexin 4.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 5 5 Phosphoserine; by TRPM7 (By similarity).
 MOD_RES 21 21 Phosphotyrosine; by EGFR (By similarity).
 MOD_RES 27 27 Phosphoserine; by PKC (By similarity).
 MOD_RES 37 37 Phosphoserine (By similarity).
 MOD_RES 312 312 N6-acetyllysine (By similarity).
 CROSSLNK 19 19 Isoglutamyl lysine isopeptide (Gln-Lys)  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Cell membrane; Cell projection; Cilium; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Membrane; Nucleus; Phospholipase A2 inhibitor; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 346 AA 

Protein Sequence

Gene Ontology

 GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
 GO:0001533; C:cornified envelope; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0031966; C:mitochondrial membrane; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; TAS:RGD.
 GO:0019834; F:phospholipase A2 inhibitor activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0005198; F:structural molecule activity; IEA:Compara.
 GO:0046632; P:alpha-beta T cell differentiation; IEA:Compara.
 GO:0050482; P:arachidonic acid secretion; IEA:Compara.
 GO:0007049; P:cell cycle; IEA:Compara.
 GO:0007166; P:cell surface receptor signaling pathway; IDA:RGD.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IDA:BHF-UCL.
 GO:0070301; P:cellular response to hydrogen peroxide; IMP:RGD.
 GO:0031018; P:endocrine pancreas development; IEP:RGD.
 GO:0060206; P:estrous cycle phase; IEP:RGD.
 GO:0042063; P:gliogenesis; IEP:RGD.
 GO:0070365; P:hepatocyte differentiation; IEP:RGD.
 GO:0030073; P:insulin secretion; IDA:RGD.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0002674; P:negative regulation of acute inflammatory response; IDA:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0050709; P:negative regulation of protein secretion; IMP:RGD.
 GO:0097350; P:neutrophil clearance; IEA:Compara.
 GO:0018149; P:peptide cross-linking; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
 GO:0033031; P:positive regulation of neutrophil apoptotic process; IEA:Compara.
 GO:0031394; P:positive regulation of prostaglandin biosynthetic process; IMP:RGD.
 GO:0031340; P:positive regulation of vesicle fusion; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0070555; P:response to interleukin-1; IEP:RGD.
 GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
 GO:0010165; P:response to X-ray; IEP:RGD. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002388; AnnexinI. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00197; ANNEXINI.