UniProt Accession

 TBE_HUMAN; Q9UJT0; Q5H8W8; Q8NEG3 

Genbank Protein ID

 AF201334; Z99289; CH471051; BC025405; BC031101 

Genbank Nucleotide ID

 AAF09585.1; CAI42327.1; EAW48272.1; AAH25405.1; AAH31101.1 

Protein Name

 Tubulin epsilon chain 

Protein Synonyms/Alias

 Epsilon-tubulin 

Gene Name

 TUBE1 

Gene Synonyms/Alias

 TUBE 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	EHAAVNQKGIYDEAI	ubiquitination	[1, 2, 3]
61	GDGGSISKGKICSLK	ubiquitination	[1, 2]
63	GGSISKGKICSLKAR	ubiquitination	[2]
68	KGKICSLKARAVLID	ubiquitination	[2]
96	LRDVFDTKQLITDIS	ubiquitination	[1, 2, 3]
114	NNWAVGHKVFGSLYQ	ubiquitination	[1]
127	YQDQILEKFRKSAEH	ubiquitination	[1, 2]
229	DLMVNSGKLGTTVKP	ubiquitination	[2]
235	GKLGTTVKPKSLVTS	ubiquitination	[2]
249	SSSGALKKQHKKPFD	ubiquitination	[2]
329	MFSDAFSKDHQLLRA	ubiquitination	[2, 3]
339	QLLRADPKHSLYLAC	ubiquitination	[3]
367	RRNIERLKPSLQFVS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

 NP_BIND 148 154 GTP (Potential).  

Keyword

 Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 475 AA 

Protein Sequence

Gene Ontology

 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0000242; C:pericentriolar material; TAS:ProtInc.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc.
 GO:0007098; P:centrosome cycle; TAS:ProtInc.
 GO:0051258; P:protein polymerization; IEA:InterPro. 

Interpro

 IPR004057; Epsilon_tubulin.
 IPR008280; Tub_FtsZ_C.
 IPR000217; Tubulin.
 IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
 IPR023123; Tubulin_C.
 IPR017975; Tubulin_CS.
 IPR003008; Tubulin_FtsZ_GTPase. 

Pfam

 PF00091; Tubulin
 PF03953; Tubulin_C 

SMART

 SM00864; Tubulin
 SM00865; Tubulin_C 

PROSITE

 PS00227; TUBULIN 

PRINTS

 PR01519; EPSLNTUBULIN.
 PR01161; TUBULIN.