CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Mll2 
Protein Synonyms/Alias
  
Gene Name
 Kmt2d 
Gene Synonyms/Alias
 Mll2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1638ESKKRKRKPYRPGIGacetylation[1]
2045KMGDVARKTERPALHacetylation[1]
2195STPDPFLKPRCPSLDacetylation[1]
2417DPFAPLHKPPRPQPPacetylation[1]
2705VVGLPSSKLGGPILGacetylation[1]
3046LVESANEKAEREALLacetylation[1]
3087TSVLPEVKPKVEEGGacetylation[1]
3089VLPEVKPKVEEGGRHacetylation[1]
3123TPLSLGLKPGQTVMGacetylation[1]
3152SSGHTAEKGPFGATGacetylation[1]
3400KAKMVALKGIKKVMAacetylation[1]
3990LGPGMPVKPLQHFSSacetylation[1]
4365DNLPEAQKPEQSSLAacetylation[1]
4393EPSHLSIKQEPREEPacetylation[1]
4442AGHLLLQKLLRAKNVacetylation[1]
4493KEDAAARKPLMAKPKacetylation[1]
4498ARKPLMAKPKRVQKTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Methyltransferase; Nucleus; Reference proteome; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5514 AA 
Protein Sequence
MDSQKPPAED KDSDPAADGL AAPEKPGATE PHLPILCIGE VSVPSSGSSR LQKPPHDCSG 60
GPARRCALCN CGEPSLHGQR ELQRFELPSD WPGFPVVSSG GSSGPCEAVL PNEDLSQIGF 120
PEGLTPAHLG EPGGHCWAHH WCAAWSAGVW GQEGPELCGV DKAVFSGISQ RCSHCARFGA 180
SVPCRSPGCS RLYHFPCATA SGSFLSMRTL QLLCPEHSDG AAHLEEAHCA VCEGPGELCD 240
LFFCTSCGHH YHGACLDTAL TARKRAGWQC PECKVCQACR KPGNDSKMLV CETCDKGYHT 300
FCLKPPIEDL PAHSWKCKTC RICRACGAGS ADLNPNSEWF ENYSLCHRCH KVQGSQPVIS 360
VAEQHPAVCS RFSPPEPGET PTEEPSALYV TCQGQPKGTH VTSVQPKEPG PLQCEAKPLG 420
REGTQLEAQL EAPLNEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP TEESPLSPPP 480
ESSPFSPLEE SPPSPALDTP LSPPPEASPL SPPFEESPLS PPPEELPSSP PPEASRLSPP 540
PEESPMSPPP EESPMSPPPE ASRLFPPFEE SPLSPPPEDS PLSPPPEASR LSPPPEDSPM 600
SPPPEDSPMS PPPEVSRFSP LPVLSHLSPL PEVSRLSPPP EESPLSPPPE DSPTSPPPEA 660
SRLSPPPEDS PASPPPEASQ LSPPHEESPA SPPPEDSLMS LPMEESPLSP LPEELRLCPQ 720
PEEPYLSPQP EEPRLCLQPE ELPLSPQSEE PCLSPVLAEP CLSSQPEELR LSPVPQEPHL 780
SPQPKQLHLS PQSEEPCLSP MPEEPCLYSQ PEELHRSPQP QEPPEEPSQC PAPKELSLFP 840
PSREPPLSPM LREPALSEPG EPPLSPLPEE LPLSLSGEPV LSPQLMPPDP LPPPLSPIIP 900
AAAPPALSPL GELEYPFGAK GDSDPESPLA APILETPISP PPEANCTDPE PVPPMILPPS 960
PGSPMGPASP ILMGPLPPPC SPLLQHSLPP PTPPPSHCSP PALPLSVPSP LSPVQKEVGV 1020
SGEAGLHEME TEKGPEPECP ALEPRATSPL PSPMGDLSCP APSPAPALDD FSGLGEDTTP 1080
LDGTGQNSGS LASELKGSPV LLDPEELIPV TPMEVYGPEC KQAEQGSPCE EQEEPGAPMA 1140
PMPPTLIKSD IVNEISNLSQ GDASASFPGS EPLLGSPDPE GAGSLSMELG VSTDVSPARD 1200
EGSLRLCTDS LPETDDSLLC DTGTATSGGK AEGDKGRRRS SPARSRIKQG RSSSFPGRRR 1260
PRGGAAHGGR GRGRARLKST TSSIETLVVA DIDSSPSKEE EEEDDDTMQN TVVLFSNTDK 1320
FVLMQDMCVV CGSFGRGAEG HLLACSQCSQ CYHPYCVNSK ITKVMLLKGW RCVECIVCEV 1380
CGQASDPSRL LLCDDCDISY HTYCLDPPLL TVPKGGWKCK WCVSCMQCGA ASPGFHCEWQ 1440
NSYTHCGPCA SLVTCPICHA PYVEEDLLIQ CRHCERWMHA GCESLFTEDE VEQAADEGFD 1500
CVSCQPYVVK PVVPVAPPEL VPVKVKEPEP QFFRFEGVWL TETGMAVLRN LTMSPLHKRR 1560
QRRGRLGLPG EAGLEGSEPS DALGPDDKKD GDLDTEELLK GEGGVEQMEC EIKLEGPASP 1620
DVELGKEETE ESKKRKRKPY RPGIGGFMIR QRKSHTRVKR GPAAQAEGSS GDGQPDEVMP 1680
ADLPAEGSVE QSLAEGDEKK KQQRRGRRKS KLEDMFPAYL QEAFFGKELL DLSRKALFAV 1740
GVGRPGFGLG TSKPRGDGGS DRKELVTALH KGDDGPDVAD EESHGPEGTA DVAGLEDGAV 1800
KASPVPSDPE KPGTPGEGVL SSDLDRIPTE ELPKMESKDL QQLFKDVLGS EREQHLGCGT 1860
PGLEGSRTPL QRPFLQGGLA LGSLPSSSPM DSYPGLCQSP FLDSRERGGF FSPEPGEPDS 1920
PWTGSGGTTP STPTTPTTEG EGDGLSYNQR SLQRWEKDEE LGQLSTISPV LYANINFPNL 1980
KQDYPDWSSR CKQIMKLWRK VPAADKAPYL QKAKDNRAAH RINKVQKQAE SQISKQAKMG 2040
DVARKTERPA LHLRIPSQPG ALGSPPPAAA PTIFLGSPTT PAGLSTSADG FLKPPAGTVP 2100
GPDSPGELFL KLPPQVPAQV PSQDPFGLAP AYAPEPRFSA APPTYPPYPS PTGAPVQPPM 2160
LGTTTRPGTG QPGEFHTTPP GTPRHQPSTP DPFLKPRCPS LDNLAVPESP GVAGGKASEP 2220
LLSPPPFGES RKSLEVKKED LGASSPGYGP PNLGCVDSPS SGPHLGGLEL KAPDVFKAPL 2280
TPRASQVEPQ SPGLGLRAQE PPPAQALAPS PPNHPDIFRS GPYPDPYAQP PLTPRPQPPP 2340
PESCCAPPPR SLPSDPFSRV PASPQSQSSS QSPLTPRPLS TEAFCPSPVT PRFQSPDPYS 2400
RPPSRPQSRD PFAPLHKPPR PQPPEVAFKA GPLAHTPLGA GGFPAALPSG PAGELHAKVP 2460
SGQPTHFARS PGTGTFAGTP SPMRFTFPQG VGEPSLKPPV PQPGLPSPHG INSHFGPGPT 2520
LGKPQSTNYA VATGNFHPSG SPLGPNSGPT GEGYGLSPLR PASVLPPPTP DGSLPYLSHG 2580
ASQRVGITSP VEKREDPGAT MSSSSVATPE LSSAQDTGMS SLSQTELEKQ RQRQRLRELL 2640
IRQQIQRNTL RQEKETAAAA AGAVGPPGNW GAEPSGPAFD QLSRAQTPFT GSQDRNSVVG 2700
LPSSKLGGPI LGPGAFSSDD RLSRPLPPAT PSSMDMNSRQ LVGGSQAFYQ RTPYPGSLPL 2760
QQQQQQQQQQ QQQQQQQQQQ QQLWQQQQAA AAAATSMRLA MSARFPSTPG PELGRQALGS 2820
PLAGIPTRLP GPAEPVPGPA GPAQFIELRH NVQKGLGPGV SPFPGQGPPQ RPRFYPISEE 2880
PHRLAPEGLR GLAVSGLPPQ KPSAPPAPEL NNSLHQPPHT KGPTLPAGLE LVSRPPSTTD 2940
LGRPPLALEA GKLPCEDPEL DDDFDAHKAL EDDEELAHLG LGVDVAKGDD ELGTLEHLET 3000
NDPHLDDLLN GDEFDLLAYT DPELDTGDKK DIFNEHLRLV ESANEKAERE ALLRGVEPIS 3060
LGPEEQRPPP APDNSEPRLT SVLPEVKPKV EEGGRHPSPC QFTINTPKVE PAPPATPLSL 3120
GLKPGQTVMG SRDTRVGVGT GPFPSSGHTA EKGPFGATGG TPAHLLNPSS LSGSAGSSLL 3180
EKFELESGTL TLPSGNVAPG DELDKMESSL VASELPLLIE DLLEHEKKEL QKRQQLSAQT 3240
VLPAQPQQQQ QQHQHPLLPV PGPAQALPLP HESGPPQQLA LGLGSTRQPG LGQSMMAAQS 3300
PAHALQQRLA PSVAMVSNQG HMLSGQQAGQ TGLVPQQSSQ PVLAQKPMNA MPASMCMKPQ 3360
QLAMQQQQLA NSFFPDTDLD KFAAEDIIDP IAKAKMVALK GIKKVMAQGS IGVAPGMNRQ 3420
QVSLLAQRLS GASGSDLQNH AAAGSGQERN ASDPSQPRPN PPTFAQGVIN EADQRQYEEW 3480
LFHTQQLLQM QLKVLEEQIG VHRKSRKALC AKQRTAKKAG REFPEADAEK LKLVTEQQSK 3540
IQKQLDQVRK QQKEHTNLMA EYRNKQQQQQ QQQQQQQQHS AVLAVSPSQN PRVLTKHPGQ 3600
LLPGHGLQPP QVPPGGQAGG LRLPPGGMVL PGQSGGPFLN TTLAQQQQQQ HSGVAGSLTG 3660
PSGSFFPGNL ALRSLGPDSR LLQERQLQLQ QQRMQLAQKL QQQQQQQQQQ QQQQLLGQVA 3720
VQQQQGPVGQ NQALGPKPQG LLPPSNHQGL LVQQLSPQQS QGSQGMLGSS QVAVLQQQQQ 3780
QQQHSGALGP QGPHRQVLMT QSRVLSSPQL AQQGHGLMGH RLLTAQQQQQ QQQQQQQQQQ 3840
QQQQGSMTGL SQLQQGMMSH GGQPKMSVQA LGSLQQQQQQ QQQLQQQQQQ MQQLQQQQQQ 3900
QLQQQQQQQM QQLQQQQQQL QQQQQQQQQQ QQLHLQQQLH QQQQLQQQQL QLQQQQQQMS 3960
LLNQNRTLLS PQQQQQQQQQ VTLGPGMPVK PLQHFSSPGA LGPALLLTGK EQNIAETALP 4020
SEVTEGPSAH QGGPPTVGTT PESMSVEPGE VKPSISGDSQ LLLVQSQPTS VQLQPPLRLP 4080
GQPQQVNLLH TTGGGSHGQQ LGSGSSSEAP SGPHLLAQPS VSLGEQPGPM AQNLLGSQQP 4140
LGLERPIQNN TGSQPPKSGP APQSGQGPPG VGVMPTVGQL RAQLQGVLAK TPQLRHLSPQ 4200
QQQQLQALLM QRQLQQSQAV RQMPPGQESG TQPSPLQGLL GCQPQPGVFS ASQIGPLQEL 4260
GAGSRPQGPP RLPVPQGALS TGPVLGPVHP TPPPSSPQEP KRPSQLPSPS AQLTPTHPGT 4320
PKPQGPASEL PPGRVSPAAA QLADAFFGKG LGPWDPSDNL PEAQKPEQSS LAAGRLEQVN 4380
GQVAHEPSHL SIKQEPREEP CALGAQTVKR EANGEPAGAP GTSNHLLLAG SRSEAGHLLL 4440
QKLLRAKNVQ LGAGRGPEGL RAEINGHVDS KLSGQEQKLQ GTSSSKEDAA ARKPLMAKPK 4500
RVQKTSDRLA SSRKKLRKED GVRANEALLK QLKQELSQLP LTEPTITANF SLFAPFGSGC 4560
LVGGQSQLRG AFGSGALHTG PDYYSQLLTK NNLSNPPTPP SSLPPTPPPS VQQKMVNGVT 4620
PSEELGEHPK DAASAQDSER TLKDAAEVKS LDLLAALPTP PHNQTEDVRM ESDEDSDSPD 4680
SIVPASSPES ILGEEAPRFP QLGSGRWEQD TRALSPVIPI IPRTSIPVFP DTKPYGVLDL 4740
EVPGKPPATA WEKGKGSEVS VMLTVSAAAA KNLNGVMVAV AELLSMKIPN SYEVLFPDGP 4800
ARAGLEPKKG ETEGSGGKEK GLSGRGPDTG PDWLKQFDAV LPGYTLKSQL DILSLLKQES 4860
PAPEPSIQHS YTYNVSNLDV RQLSAPPPEE PSPPPSPLAP SPASPPAEPM VELQAEPPAE 4920
PPIPSPLPLA SSPEATRPKP RARPPDESED SRPPRLKKWK GVRWKRLRLL LTIQKGSGRQ 4980
EDEREVAEFM EQLGTALRPS KVPRDNRRCC FCHEEGDGAT DGPARLLNLD LDLWVHLNCA 5040
LWSTEVYETQ GGALMNVEVA LHRGLLTKCS LCQRTGATGS CNRMRCPNVY HFACAIRAKC 5100
MFFKDKTMLC PMHKIKGPCE QELSSFAVFR RVYIERDEVK QIASIIQRGE RLHMFRVGGL 5160
VFHAIGQLLP HQMADFHSAT ALYPVGYEAT RIYWSLRTNN RRCCYRCSIS ENNGRPEFVI 5220
KVIEQGLEDL VFTDASPQAV WNRIIEPVAA MRKEADMLRL FPEYLKGEEL FGLTVHAVLR 5280
IAESLPGVES CQNYLFRYGR HPLMELPLMI NPTGCARSEP KILTHYKRPH TLNSTSMSKA 5340
YQSTFTGETN TPYSKQFVHS KSSQYRRLRT EWKNNVYLAR SRIQGLGLYA AKDLEKHTMV 5400
IEYIGTIIRN EVANRREKIY EEQNRGIYMF RINNEHVIDA TLTGGPARYI NHSCAPNCVA 5460
EVVTFDKEDK IIIISSRRIP KGEELTYDYQ FDFEDDQHKI PCHCGAWNCR KWMN 5514 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR003889; FYrich_C.
 IPR003888; FYrich_N.
 IPR009071; HMG_box_dom.
 IPR003616; Post-SET_dom.
 IPR001214; SET_dom.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF05965; FYRC
 PF05964; FYRN
 PF00628; PHD
 PF00856; SET 
SMART
 SM00542; FYRC
 SM00541; FYRN
 SM00398; HMG
 SM00249; PHD
 SM00508; PostSET
 SM00184; RING
 SM00317; SET 
PROSITE
 PS51543; FYRC
 PS51542; FYRN
 PS50868; POST_SET
 PS50280; SET
 PS50016; ZF_PHD_2
 PS50089; ZF_RING_2 
PRINTS