UniProt Accession

 ERLEC_HUMAN; Q96DZ1; B2RDB4; B5MC72; O95901; Q6UWN7; Q9NUY7; Q9UQL4 

Genbank Protein ID

 AY453410; AY358717; AK001913; AK315477; AC007883; CH471053; BC013129; BC022228; AF131743; AF131849 

Genbank Nucleotide ID

 AAR26725.1; AAQ89079.1; BAA91974.1; BAG37861.1; AAY24352.1; EAX00164.1; AAH13129.1; AAH22228.1; AAD20029.1; AAD20060.1 

Protein Name

 Endoplasmic reticulum lectin 1 

Protein Synonyms/Alias

 ER lectin; Erlectin; XTP3-transactivated gene B protein 

Gene Name

 ERLEC1 

Gene Synonyms/Alias

 C2orf30; XTP3TPB; UNQ1878/PRO4321 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	SGDEEEEKDYKGPNP	ubiquitination	[1]
96	EEEEKDYKGPNPREL	ubiquitination	[1]
109	ELLEPLFKQSSCSYR	ubiquitination	[1]
157	YLGNMLAKNLLFEKE	ubiquitination	[2]
179	KSNEIPTKNIEGQMT	ubiquitination	[1]
202	NGTPCSLKQNRPRSS	ubiquitination	[2]
270	SLPGSPFKPLTLRQL	ubiquitination	[1]
300	EEDLQSTKEERFPAI	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins. 

Sequence Annotation

 DOMAIN 111 180 PRKCSH 1.
 DOMAIN 342 418 PRKCSH 2.
 CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycoprotein; Polymorphism; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0005788; C:endoplasmic reticulum lumen; IDA:UniProtKB.
 GO:0001948; F:glycoprotein binding; IDA:UniProtKB.
 GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB. 

Interpro

 IPR009011; Man6P_isomerase_rcpt-bd_dom.
 IPR012913; PRKCSH. 

Pfam

 PF07915; PRKCSH 

SMART

  

PROSITE

  

PRINTS