UniProt Accession

 PIGW_HUMAN; Q7Z7B1; Q8N9G3 

Genbank Protein ID

 AB097818; AK094752 

Genbank Nucleotide ID

 BAC77021.1; BAC04413.1 

Protein Name

 Phosphatidylinositol-glycan biosynthesis class W protein 

Protein Synonyms/Alias

 PIG-W 

Gene Name

 PIGW 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	YARLPFLKILEKFLN	ubiquitination	[1, 2, 3]
412	ALVPCSWKLIQSPVT	ubiquitination	[1, 3]
421	IQSPVTNKKHSESLV	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity). 

Sequence Annotation

 CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).  

Keyword

 Acyltransferase; Complete proteome; Endoplasmic reticulum; Glycoprotein; GPI-anchor biosynthesis; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 504 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
 GO:0006501; P:C-terminal protein lipidation; TAS:Reactome.
 GO:0016254; P:preassembly of GPI anchor in ER membrane; TAS:Reactome. 

Interpro

 IPR009447; GWT1. 

Pfam

 PF06423; GWT1 

SMART

  

PROSITE

  

PRINTS