UniProt Accession

 YGHA_ECOLI; P0AG84; P25887; Q2M9J4; Q46852 

Genbank Protein ID

 U28377; U00096; AP009048; M28819 

Genbank Nucleotide ID

 AAA69170.1; AAC76039.1; BAE77062.1 

Protein Name

 Uncharacterized oxidoreductase YghA 

Protein Synonyms/Alias

  

Gene Name

 yghA 

Gene Synonyms/Alias

 b3003; JW2972 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
5	***MSHLKDPTTQYY	acetylation	[1]
18	YYTGEYPKQKQPTPG	acetylation	[1]
20	TGEYPKQKQPTPGIQ	acetylation	[1]
39	PVPDCGEKTYVGSGR	acetylation	[1, 2]
92	EEDAQDVKKIIEECG	acetylation	[1]
101	IIEECGRKAVLLPGD	acetylation	[1]
113	PGDLSDEKFARSLVH	acetylation	[1]
124	SLVHEAHKALGGLDI	acetylation	[1, 3]
220	LAKQVAEKGIRVNIV	acetylation	[1]
246	SGGQTQDKIPQFGQQ	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842]
 [3] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

  

Sequence Annotation

 NP_BIND 53 77 NAD or NADP (By similarity).
 ACT_SITE 199 199 Proton acceptor (By similarity).
 BINDING 186 186 Substrate (By similarity).
 MOD_RES 39 39 N6-acetyllysine.  

Keyword

 Acetylation; Complete proteome; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 294 AA 

Protein Sequence

Gene Ontology

 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.