UniProt Accession

 SMD3_HUMAN; P62318; B5BU13; P43331 

Genbank Protein ID

 U15009; CR456583; AB451249; AB451373; CH471095; BC000457; BC003150 

Genbank Nucleotide ID

 AAA57034.1; CAG30469.1; BAG70063.1; BAG70187.1; EAW59670.1; AAH00457.1; AAH03150.1 

Protein Name

 Small nuclear ribonucleoprotein Sm D3 

Protein Synonyms/Alias

 Sm-D3; snRNP core protein D3 

Gene Name

 SNRPD3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MSIGVPIKVLHEAEG	ubiquitination	[1]
78	LILPDMLKNAPMLKS	ubiquitination	[1, 2]
84	LKNAPMLKSMKNKNQ	ubiquitination	[1]
104	RGKAAILKAQVAARG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. 

Sequence Annotation

 REPEAT 110 111 1.
 REPEAT 112 113 2.
 REPEAT 114 115 3.
 REPEAT 116 117 4.
 REPEAT 118 119 5.
 REGION 110 119 5 X 2 AA tandem repeats of [RM]-G.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; RNA-binding; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 126 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005689; C:U12-type spliceosomal complex; IDA:UniProtKB.
 GO:0005683; C:U7 snRNP; IDA:UniProtKB.
 GO:0071208; F:histone pre-mRNA DCP binding; ISS:UniProtKB.
 GO:0008334; P:histone mRNA metabolic process; TAS:Reactome.
 GO:0031124; P:mRNA 3'-end processing; TAS:Reactome.
 GO:0034660; P:ncRNA metabolic process; TAS:Reactome.
 GO:0000387; P:spliceosomal snRNP assembly; TAS:Reactome.
 GO:0006369; P:termination of RNA polymerase II transcription; TAS:Reactome. 

Interpro

 IPR027141; LSm4/Sm_D1/D3.
 IPR010920; LSM_dom.
 IPR001163; Ribonucl_LSM.
 IPR006649; Ribonucl_LSM_euk/arc. 

Pfam

 PF01423; LSM 

SMART

 SM00651; Sm 

PROSITE

  

PRINTS