UniProt Accession

 TLX1_HUMAN; P31314; A1L4G3; O75699; Q5VXP2; Q9HCA0; Q9UD59 

Genbank Protein ID

 M62626; M75952; S38742; AJ009794; AL357395; CH471066; BC130530; AF067443 

Genbank Nucleotide ID

 AAA36719.1; AAA58662.1; AAB19293.1; CAA08834.1; CAH72448.1; EAW49778.1; AAI30531.1; AAG10096.1 

Protein Name

 T-cell leukemia homeobox protein 1 

Protein Synonyms/Alias

 Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3 

Gene Name

 TLX1 

Gene Synonyms/Alias

 HOX11; TCL3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
236	AERAALAKALKMTDA	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. 

Sequence Annotation

 DNA_BIND 201 260 Homeobox.
 MOD_RES 236 236 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Chromosomal rearrangement; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Proto-oncogene; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 330 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045165; P:cell fate commitment; IEA:Compara.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0048645; P:organ formation; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048536; P:spleen development; IEA:Compara. 

Interpro

 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00024; HOMEOBOX.