CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034065
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 Asap2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
212VNEIKVKKGVDLLQNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ANK repeat; Complete proteome; Metal-binding; Reference proteome; Repeat; SH3 domain; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 955 AA 
Protein Sequence
MPDQISVSEF VAETHEDYKA PTASSFTTRT AQCRNTVAAI EEALDVDRMV LYKMKKSVKA 60
INISGLAHVE NEEQYTQALE KFGGNCVCRD DPDLGSAFLK FSVFTKELTA LFKNLIQNMN 120
NIISFPLDSL LKGDLKGVKG DLKKPFDKAW KDYETKITKI EKEKKEHAKL HGMIRTEISG 180
AEIAEEMEKE RRFFQLQMCE YLLKVNEIKV KKGVDLLQNL IKYFHAQCNF FQDGLKAVES 240
LKPSIETLST DLHTIKQAQD EERRQLIQLR DILKSALQVE QKEDSQLRQS TAYSLHQPQG 300
NKEHGTERNG NLYKKSDGIR KVWQKRKCSV KNGFLTISHG TANRPPAKLN LLTCQVKTNP 360
EEKKCFDLIS HDRTYHFQAE DEQECQIWMS VLQNSKEEAL NNAFKGDDNT GENNIVQELT 420
KEIISEVQRM TGNDVCCDCG APDPTWLSTN LGILTCIECS GIHRELGVHY SRMQSLTLDV 480
LGTSELLLAK NIGNAGFNEI MECCLPSEDP VKPNPGSDMI ARKDYITAKY MERRYARKKH 540
ADTAAKLHSL CEAVKTRDIF GLLQAYADGV DLTEKIPLAN GHEPDETALH LAVRSVDRTS 600
LHIVDFLVQN SGNLDKQTGK GSTALHYCCL TDNAECLKLL LRGKASIEIA NESGETPLDI 660
AKRLKHEHCE ELLTQALSGR FNSHVHVEYE WRLLHEDLDE SDDDVDEKLQ PSPNRREDRP 720
VSFYQLGSSQ FQSNAVSLAR DTANLTKDKQ RGFGPSILQN ETYGAILSGS PPSSQSIPPS 780
TTSAPPLPPR NVGKDPLTTT PPPPVAKTSG TLEAMNQPSK SSQPGTSQSK PPPLPPQPPS 840
RLPQKKPASG TDKPTPLTNK GQPRGPEASG PLSNAMALQP PAPMPRKSQA TKSKPKRVKA 900
LYNCVADNPD ELTFSEGDVI IVDGEEDQEW WIGHIDGEPS RKGAFPVSFV HFIAD 955 
Gene Ontology
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro. 
Interpro
 IPR027267; AH/BAR-dom.
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR001164; ArfGAP.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain. 
Pfam
 PF12796; Ank_2
 PF01412; ArfGap
 PF00169; PH
 PF00018; SH3_1 
SMART
 SM00248; ANK
 SM00105; ArfGap
 SM00233; PH
 SM00326; SH3 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50115; ARFGAP
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS
 PR00405; REVINTRACTNG.