UniProt Accession

 LMAN1_MOUSE; Q9D0F3 

Genbank Protein ID

 AK011495; BC057165 

Genbank Nucleotide ID

 BAB27655.1; AAH57165.1 

Protein Name

 Protein ERGIC-53 

Protein Synonyms/Alias

 ER-Golgi intermediate compartment 53 kDa protein; Lectin mannose-binding 1; p58 

Gene Name

 Lman1 

Gene Synonyms/Alias

 Ergic53 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
354	NRIHLEIKQLNRQLD	acetylation	[1]
354	NRIHLEIKQLNRQLD	ubiquitination	[2]
454	KEHLHVVKRDIDSLA	acetylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity). 

Sequence Annotation

 DOMAIN 52 275 L-type lectin-like.
 REGION 259 261 Carbohydrate binding (By similarity).
 MOTIF 516 517 ER export motif (By similarity).
 METAL 160 160 Calcium (By similarity).
 METAL 162 162 Calcium; via carbonyl oxygen (By
 METAL 164 164 Calcium (By similarity).
 METAL 189 189 Calcium (By similarity).
 BINDING 96 96 Carbohydrate (By similarity).
 BINDING 129 129 Carbohydrate (By similarity).
 BINDING 164 164 Carbohydrate (By similarity).
 BINDING 186 186 Carbohydrate (By similarity).
 DISULFID 198 238 By similarity.
 DISULFID 473 473 Interchain (By similarity).
 DISULFID 482 482 Interchain (By similarity).  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Lectin; Membrane; Metal-binding; Protein transport; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:MGI.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030017; C:sarcomere; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007029; P:endoplasmic reticulum organization; IMP:MGI.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; TAS:MGI.
 GO:0007030; P:Golgi organization; IEA:Compara.
 GO:0010638; P:positive regulation of organelle organization; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR005052; Lectin_leg. 

Pfam

 PF03388; Lectin_leg-like 

SMART

  

PROSITE

 PS51328; L_LECTIN_LIKE 

PRINTS