CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ataxia telangiectasia mutated homolog (Human) (Mapped), isoform CRA_a 
Protein Synonyms/Alias
 Protein Atm 
Gene Name
 Atm 
Gene Synonyms/Alias
 Atm_mapped; rCG_58300 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
796HTKHTLNKIASGFFLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3064 AA 
Protein Sequence
MSLALNDLLI CCRQLEHDRA TERRKEVDKF KRLIQDPETV QHLDRHSDSK QGKYLNWDAV 60
FRFLQKYIQK ETESLRTAKS NVSASTQTSR QKKMQEISSL VRFFIKCANK RAPRLKCQDL 120
LNYVMDTVKD SSNGATYGAD CSNILLKDIL SVRKYWCEVS QQQWLELFSL YIRLYLKPSQ 180
DINRVLVARI IHAVTRGCCS QTDGLPSKFL DLFSKAIQYA RQEKSSPGLS HILAALNIFL 240
KTLAVNFRKR VCEIGDEILP TLLYIWTQHR LNDSLKEVII ELIHLQIYIH HPQGAKAPEE 300
GAYESMKWKR ILYNLYDLLV NEISHIGSRG KYSSGSRNIA VKENLIDLMA DVCYQLFNAD 360
TRSVEISQSY ATQRESTDYS VPCKRRKIDI GWEVIKDYLQ KSQNDFDLVP WLQITTRLIS 420
KYPSSLPNCE LSPLILILYQ LLPQQRRGER IPHVLRCLTE VALCQGKKSN LESSQKSDLL 480
KLWIKIWSIT FRGISSEQTQ TENFGLLGAI IQGSLVELDR EFWKLFTGSA CKPSSPSVRC 540
LTLALSMCVV PDAIKMGTEQ SVCDANRSFS VKESIMRWLL FYQLEGDLED SAEPPPILQS 600
NFPHLILEKI LVSLTMKNSK AAMKFFQSAP ECEQHCEDTE EPSFSEAEEL FLQTTFDKMD 660
FLTPVKEDTV EKFQSRVGFS VHQNLKESLD HYLLGLSEQL LSNYSSEITS SETLVRCSSL 720
LVGVLGCYCY MGVITEDEAY KSELFQKAKS LMQCAGESIS LFKNKTNEES RVGSLRSVIH 780
LCTSCLCRHT KHTLNKIASG FFLRLLTSKL MNDIADICKS LASCTKKPFD YGEEHSLRDD 840
DDDGDGGDGG ESLMETQGSS STDLFSDYSA STVSDANDYG ENQNAVGAAN PLTADWLSRQ 900
DHLLLDMLRF LCLSVTACQS RTASFRGADI RRKLLMLLDP STLDLTKSLH LHMYLVLLKD 960
LPGKEHLLPM EDVVELLQPL SLVCSLYRRD QDVCKTILSN VLHIVTNLGQ GSVDTESTRN 1020
AQGQFLTVMG AFWHLTKEKK CIFSVRMALV KCLQTLLEAD PYSKWAILNV KGQDFPVREA 1080
FPQFLADGHH HVRMLAAGSI SRLFQDMRQG DSSRSLKALP LKFQQTSFNS AYMIAEAGIR 1140
ELLCDSQNPD LLDEIYNRKS VLLTVIAVVL HCSPICEKQA LFALCKSVKE NGLEPHLVKK 1200
VLEKVSESFG CRCLEDFMAS HLDYLVLEWL NLQDAKYSLS SFPFTLLNYM SVEDFYRSCY 1260
KILIPHLVIR KHFDEVKSIA NQIQRCWKSL LIDCFPKMLV HILPYFACEG TGDSSSAQKR 1320
ETATEVYDTL KGEDFLGKQI DQVFISNLPE IVVELLMTLH ETADSDSGQS PDLCDFSGDL 1380
DPAPNPPYFP SHVIKATFAY ISSCHKTKFK SILEILSKIP DSYQKILLAI CEQAAETNNV 1440
FKKHRILKIY HLFVSLLLKD IQSGLGGAWA FVLRDVIYTL IHYINKRSSH FTDVSLRSFS 1500
LCCDLLSRVC RTAVTHCKDA LENHLHVIVG TLIPLVDYQE VQEQVLDLLK YLVIDNKDNK 1560
NLFVTIKLLD PFPDHVVFKD LRLTQQKIKY SGGPFTLLEE INHFLSVSAY NPLPLTRLEG 1620
LKDLRRQLEQ HKDQMLDLVR ASQDNPQDGI VVKLVVSLLQ LSKMAVNQTG EREVLEAVGR 1680
CLGEIGPLDF STIAVQHSKD TPYTKAYGLP EDRELQWTLI MLTALNNTLV EDSVKIRSAA 1740
ATCLKNILAT KTGHIFWENH KTSADPMLTY LQPFRASRKK FLELPQFVKE DALEGLDDVN 1800
LWVPQSESHD IWIKTLTCAF LDSGGIKSEI LQLLKPMCEV KTDFCQMVLP YLIHDVLLQD 1860
THESWRTLLS THVRGFFTNC FKHSSQASRS ATPANSDSES ENFLRCCLDK KSQRTMLAVV 1920
DYLRRQKRPS SGTAFEDAFW LDLNYLEVAK VAQSCAAHFT ALLYAEIYSD KKNMDEQEKR 1980
SPTFEEGSQG TTISSLSEKS KEETGISLQD LLLEIYRSIG EPDSLYGCGG GKVLQPLTRI 2040
RTYEHEATWE KALVTYDLET TISSSTRQSG IIQALQNLGL SHILSIYLKG LDHERREWCG 2100
ELQELHYQAA WRNMQWDLCT SANQELEGTS YHESLYNALQ CLRNREFSTF YDSLRHARVK 2160
EVEELSKGSL ESVYSLYPTL SRLQAVGELE NSGELFSRSV TDRERSEVYL KWQKHSQLLK 2220
DSDFSFQEPL MALRTVILEI LVQKEMENSQ GGCSKDILTK HLVEFSVLAR TFKNTQLPER 2280
AIFKIKQYNP AICGISEWHL EEAQVFWAKK EQSLALSILK QMIKKLDSSF REVCNEAGLK 2340
GLHAECLRVC GNWLAETCLE NPAVIMQTYL EKAVKVAGSY DGDSRELRNG QMKAFLSLAR 2400
FSDTQYQRIE NYMKSSEFEN KQALLKRAKE EVGLIREHKI QTNRYTIKVQ RELELDECAL 2460
RALKEDRKRF LCKAVENYIS CLLSGEEHDL WVFRLCSLWL ENSGVSEVNG MMKRDGMKIS 2520
SYKFLPLMYQ LAARMGTKMT GGLGFHEVLN NLISRISMDH PHHTLFIILA LANANKDEFL 2580
SKPETARRGR ITKNAPKESS QLDEDRAEAA SRIIHTIRSA RRTMVKDMEA LCDAYIILAN 2640
LDASQWRNQR KGISIPANQP ITKLKNLEDV VVPTMEIKVD PTGEYEKLVT IKSFKTEFRL 2700
AGGLNLPKII DCVGSDGKER RQLVKGRDDL RQDAVMQQVF QMCNMLLQRN TETRKRKLTI 2760
CTYKVVPLSQ RSGVLEWCTG TIPIGEYLVN NEEGAHKRYR PNDLSANQCQ KKMMEVQKKS 2820
FEEKYETFMT ICQNFEPVFR YFCMEKFLDP AVWFEKRLAY TRSVATSSIV GYILGLGDRH 2880
VQNILINEQS AELVHIDLGV AFEQGKILPT PETVPFRLSR DIVDGMGITG VEGVFRRCCE 2940
KTMEVMRSSQ EALLTIVEVL LYDPLFDWTM NPLKALYLQQ RPEDETDLQS TPSADDQECK 3000
RSLSDTDQSF NKVAERVLMR LQEKLKGVEE GTVLSVGGQV NLLIQQAMDP KNLSRLFPGW 3060
KAWV 3064 
Gene Ontology
 GO:0000781; C:chromosome, telomeric region; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004677; F:DNA-dependent protein kinase activity; IEA:Compara.
 GO:0035174; F:histone serine kinase activity; IDA:RGD.
 GO:0006915; P:apoptotic process; IEP:RGD.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0071480; P:cellular response to gamma radiation; IEA:Compara.
 GO:0006975; P:DNA damage induced protein phosphorylation; IEA:Compara.
 GO:0006281; P:DNA repair; IEA:Compara.
 GO:0007292; P:female gamete generation; IEA:Compara.
 GO:0031572; P:G2 DNA damage checkpoint; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0071044; P:histone mRNA catabolic process; IEA:Compara.
 GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Compara.
 GO:0042159; P:lipoprotein catabolic process; IEA:Compara.
 GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030889; P:negative regulation of B cell proliferation; IEA:Compara.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0002331; P:pre-B cell allelic exclusion; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IDA:RGD.
 GO:0051726; P:regulation of cell cycle; IMP:RGD.
 GO:0090399; P:replicative senescence; IEA:InterPro.
 GO:0006974; P:response to DNA damage stimulus; IDA:RGD.
 GO:0001666; P:response to hypoxia; IDA:RGD.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0000723; P:telomere maintenance; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR015519; ATM/Tel1.
 IPR003152; FATC.
 IPR011009; Kinase-like_dom.
 IPR000403; PI3/4_kinase_cat_dom.
 IPR018936; PI3/4_kinase_CS.
 IPR003151; PIK-rel_kinase_FAT.
 IPR014009; PIK_FAT.
 IPR021668; TAN. 
Pfam
 PF02259; FAT
 PF02260; FATC
 PF00454; PI3_PI4_kinase
 PF11640; TAN 
SMART
 SM00146; PI3Kc 
PROSITE
 PS51189; FAT
 PS51190; FATC
 PS00915; PI3_4_KINASE_1
 PS00916; PI3_4_KINASE_2
 PS50290; PI3_4_KINASE_3 
PRINTS