UniProt Accession

 PNRC2_HUMAN; Q9NPJ4; B4DU72 

Genbank Protein ID

 AF374386; AF151042; AK000319; AK300522; AL590609; BC001959; BC078177; BC085018 

Genbank Nucleotide ID

 AAK54613.1; AAF36128.1; BAA91082.1; BAG62234.1; CAI14802.1; AAH01959.1; AAH78177.1; AAH85018.1 

Protein Name

 Proline-rich nuclear receptor coactivator 2 

Protein Synonyms/Alias

  

Gene Name

 PNRC2 

Gene Synonyms/Alias

 HSPC208 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	PQSRNVSKNQQQLNR	ubiquitination	[1]
37	KEQNSQMKIVHKKKE	ubiquitination	[1]
86	SGPRLLFKSQANQNY	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. 

Sequence Annotation

 MOTIF 99 105 SH3-binding.  

Keyword

 3D-structure; Activator; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 139 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; TAS:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR026781; PNRC2. 

Pfam

  

SMART

  

PROSITE

  

PRINTS