UniProt Accession

 BAMBI_HUMAN; Q13145 

Genbank Protein ID

 U23070; U29189; U29188; BT006820; AL161936; BC019252 

Genbank Nucleotide ID

 AAC50435.1; AAR02414.1; AAR02414.1; AAP35466.1; CAC16002.1; AAH19252.1 

Protein Name

 BMP and activin membrane-bound inhibitor homolog 

Protein Synonyms/Alias

 Non-metastatic gene A protein; Putative transmembrane protein NMA 

Gene Name

 BAMBI 

Gene Synonyms/Alias

 NMA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
83	TTDICQAKQARNHSG	ubiquitination	[1]
146	VQELTSSKELWFRAA	ubiquitination	[2]
241	QADLSNDKILSLVHW	ubiquitination	[3, 4]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Negatively regulates TGF-beta signaling. 

Sequence Annotation

 CARBOHYD 87 87 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:BHF-UCL.
 GO:0005114; F:type II transforming growth factor beta receptor binding; TAS:BHF-UCL.
 GO:0016477; P:cell migration; IDA:BHF-UCL.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IDA:BHF-UCL.
 GO:0035413; P:positive regulation of catenin import into nucleus; IMP:BHF-UCL.
 GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.
 GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.
 GO:0032092; P:positive regulation of protein binding; IMP:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0008360; P:regulation of cell shape; IMP:BHF-UCL.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome. 

Interpro

 IPR009345; BMP/activin_membr-bound_inhib. 

Pfam

 PF06211; BAMBI 

SMART

  

PROSITE

  

PRINTS