CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025909
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative uncharacterized protein DKFZp686L20222 
Protein Synonyms/Alias
  
Gene Name
 DKFZp686L20222 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
9EDYTKIEKIGEGTYGubiquitination[1]
33TGQVVAMKKKKIRLEubiquitination[2]
58IREISLLKELRHPNIubiquitination[1, 3]
145QNLLIDDKGTIKLADubiquitination[1, 3]
149IDDKGTIKLADFGLAubiquitination[1]
207FAELATKKPLFHGDSubiquitination[1, 3]
285PAKRISGKMALNHPYubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 303 AA 
Protein Sequence
MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKKKIRLE SEEEGVPSTA IREISLLKEL 60
RHPNIVSLQD VLMQDSRLYL IFEFLSMDLK KYLDSIPPGQ YMDSSLVKVK AQSYLYQILQ 120
GIVFCHSRRV LHRDLKPQNL LIDDKGTIKL ADFGLARAFG IPIRVYTHEV VTLWYRSPEV 180
LLGSARYSTP VDIWSIGTIF AELATKKPLF HGDSEIDQLF RIFRALGTPN NEVWPEVESL 240
QDYKNTFPKW KPGSLASHVK NLDENGLDLL SKMLIYDPAK RISGKMALNH PYFNDLDNQI 300
KKM 303 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0035173; F:histone kinase activity; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0030261; P:chromosome condensation; IEA:Compara.
 GO:0000278; P:mitotic cell cycle; IEA:Compara.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0045931; P:positive regulation of mitotic cell cycle; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0014075; P:response to amine stimulus; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0046688; P:response to copper ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0055015; P:ventricular cardiac muscle cell development; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS