CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012826
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Homer protein homolog 1 
Protein Synonyms/Alias
 Homer-1 
Gene Name
 HOMER1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Bos taurus (Bovine) 
NCBI Taxa ID
 9913 
Lysine Modification
Position
Peptide
Type
References
212TANVKQWKQQLAAYQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). 
Sequence Annotation
 DOMAIN 1 110 WH1.  
Keyword
 Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MGEQPIFSTR AHVFQIDPNT KKNWVPTSKH AVTVSYFYDS TRNVYRIISL DGSKAIINST 60
ITPNMTFTKT SQKFGQWADS RANTVYGLGF SSEHHLSKFA EKFQEFKEAA RLAKEKSQEK 120
MELTSTPSQE SAGGDLQSPL TPESINGTDD ERTPDLTQNS EPRPEPTQNA LPFTHSSAIS 180
KHWEAELATL KGNNAKLTAA LLESTANVKQ WKQQLAAYQE EAERLHKRVT ELECVSSQAN 240
AVHTHKTELN QTIQELEETL KVKEEEIERL KQEIDNAREL QEQRDSLTQK LQEVEIRNKD 300
LEGQLSDLEQ RLEKSQNEQE AFRNNLKTLL EILDGKIFEL TELRDNLAKL LERS 354 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0043034; C:costamere; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0048148; P:behavioral response to cocaine; IEA:Compara.
 GO:0048875; P:chemical homeostasis within a tissue; IEA:Compara.
 GO:0051928; P:positive regulation of calcium ion transport; IEA:Compara.
 GO:0090279; P:regulation of calcium ion import; IEA:Compara.
 GO:2001257; P:regulation of cation channel activity; IEA:Compara.
 GO:2001256; P:regulation of store-operated calcium entry; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara.
 GO:0048741; P:skeletal muscle fiber development; IEA:Compara. 
Interpro
 IPR000697; EVH1.
 IPR011993; PH_like_dom. 
Pfam
 PF00568; WH1 
SMART
 SM00461; WH1 
PROSITE
 PS50229; WH1 
PRINTS