UniProt Accession

 B3KQZ9_HUMAN; B3KQZ9 

Genbank Protein ID

 AC074143; AK090673 

Genbank Nucleotide ID

 BAG52211.1 

Protein Name

 Tumor necrosis factor receptor type 1-associated DEATH domain protein 

Protein Synonyms/Alias

 cDNA FLJ33354 fis, clone BRACE2005124, highly similar to Tumor necrosis factor receptor type1-associated DEATH domain protein 

Gene Name

 TRADD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	EDALRNLKCGSGARG	ubiquitination	[1]
169	FARSVGLKWRKVGRS	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Receptor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0006917; P:induction of apoptosis; IEA:InterPro.
 GO:0051798; P:positive regulation of hair follicle development; IEA:Compara.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:InterPro. 

Interpro

 IPR011029; DEATH-like_dom.
 IPR000488; Death_domain.
 IPR009095; TRADD_N. 

Pfam

 PF00531; Death
 PF09034; TRADD_N 

SMART

 SM00005; DEATH 

PROSITE

 PS50017; DEATH_DOMAIN 

PRINTS