CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004791
UniProt Accession
Genbank Protein ID
 U07177 
Genbank Nucleotide ID
Protein Name
 L-lactate dehydrogenase C chain 
Protein Synonyms/Alias
 LDH-C; LDH testis subunit; LDH-X 
Gene Name
 Ldhc 
Gene Synonyms/Alias
 Ldh-3; Ldh3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
5***MSTVKEQLIQNLacetylation[1]
17QNLAPDEKQSRCKITacetylation[1]
59DADENKLKGEALDLLacetylation[1]
90YSVSANSKLVIITAGacetylation[1]
224AIGSDSDKEQWKTVHacetylation[1]
317TEEEALFKKSCDILWacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Possible role in sperm motility (By similarity). 
Sequence Annotation
 NP_BIND 29 57 NAD (By similarity).
 ACT_SITE 193 193 Proton acceptor (By similarity).
 BINDING 99 99 NAD (By similarity).
 BINDING 106 106 Substrate (By similarity).
 BINDING 138 138 NAD or substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 BINDING 248 248 Substrate (By similarity).
 MOD_RES 2 2 Blocked amino end (Ser).  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Glycolysis; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MSTVKEQLIQ NLAPDEKQSR CKITVVGVGN VGMACAISIL LKGLADELAL VDADENKLKG 60
EALDLLHGSL FLSTPKIVFG KDYSVSANSK LVIITAGARM VSGESRLALL QRNVTSMKAI 120
VPGVIQNSPD CKIMIVTNPV DILTYVVWKI SGLPVSSVIG SGCNLDSARF RYLIGEKLGV 180
NPSSCHGWVL GEHGDSSVPI WSGVNIAGVT LKSLNPAIGS DSDKEQWKTV HKQVVDGGYE 240
VLNLKGYTSW AIALSVTDIA ASILKNLKRV HAVTTLVKGL YGIKEEIFLS IPCVLGQSGI 300
TDLVKVNMNT EEEALFKKSC DILWNIQKDL QL 332 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 
SMART
  
PROSITE
 PS00064; L_LDH 
PRINTS
 PR00086; LLDHDRGNASE.