| Tag | Content |
|---|
| CPLM ID | CPLM-000240 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Suppressor of cytokine signaling 6 |
Protein Synonyms/Alias | SOCS-6; Cytokine-inducible SH2 protein 4; CIS-4; Suppressor of cytokine signaling 4; SOCS-4 |
Gene Name | SOCS6 |
Gene Synonyms/Alias | CIS4; SOCS4 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 114 | SSAPIVFKDVRAQRP | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. |
Sequence Annotation | DOMAIN 384 491 SH2.
DOMAIN 486 535 SOCS box. |
Keyword | 3D-structure; Complete proteome; Growth regulation; Reference proteome; SH2 domain; Signal transduction inhibitor; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 535 AA |
Protein Sequence | MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED 60
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR 120
PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS 180
ETTCQEQANS LKSSASHNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLDEG MYPLEGSRSY 240
CLDSSSPMEV SAVPPQVGGR AFPEDESQVD QDLVVAPEIF VDQSVNGLLI GTTGVMLQSP 300
RAGHDDVPPL SPLLPPMQNN QIQRNFSGLT GTEAHVAESM RCHLNFDPNS APGVARVYDS 360
VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL 420
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS 480
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY 535 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0001772; C:immunological synapse; IDA:MGI. GO:0006952; P:defense response; TAS:ProtInc. GO:0007259; P:JAK-STAT cascade; TAS:ProtInc. GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW. GO:0050868; P:negative regulation of T cell activation; IEA:Compara. GO:0010498; P:proteasomal protein catabolic process; IMP:MGI. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. |
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