CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014192
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP synthase subunit s, mitochondrial 
Protein Synonyms/Alias
 ATP synthase-coupling factor B; Mitochondrial ATP synthase regulatory component factor B 
Gene Name
 Atp5s 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
196ALPSLELKLNLK***acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway. 
Sequence Annotation
 REPEAT 62 87 LRR 1.
 REPEAT 88 116 LRR 2.
 REPEAT 117 141 LRR 3.
 REPEAT 142 173 LRR 4.
 REGION 1 61 N-terminal domain.
 METAL 59 59 Magnesium; via carbonyl oxygen (By
 METAL 93 93 Magnesium (By similarity).  
Keyword
 ATP synthesis; CF(0); Complete proteome; Hydrogen ion transport; Ion transport; Leucine-rich repeat; Magnesium; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transit peptide; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 200 AA 
Protein Sequence
MMMFGKISRQ LFSLKKIPWS CDSRYFWEWL NTVFNKVDYE RIKDVGPDRA ASEWLLRCGA 60
KVRYCGHQKW LQDYNKLPGG SVDRYKIQAI DATDSCIMDI GFDHLVGLEH VERITLCRCH 120
YIEDNCLQRL SQLENLRKSL LELEIIACGN VTDNGVIALR HFKNLKYLFL SDLPGIKDKE 180
YLAEVFTKAL PSLELKLNLK 200 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006754; P:ATP biosynthetic process; IEA:UniProtKB-KW.
 GO:0015992; P:proton transport; IEA:UniProtKB-KW. 
Interpro
 IPR026063; ATP_synthase_s. 
Pfam
  
SMART
  
PROSITE
 PS51450; LRR 
PRINTS