CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ELAV-like protein 3 
Protein Synonyms/Alias
 Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21 
Gene Name
 ELAVL3 
Gene Synonyms/Alias
 HUC; PLE21 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74SCKLVRDKITGQSLGubiquitination[1]
139LPKTMSQKEMEQLFSubiquitination[1]
209FANNPSQKTGQALLTubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance. 
Sequence Annotation
 DOMAIN 39 117 RRM 1.
 DOMAIN 125 205 RRM 2.
 DOMAIN 284 362 RRM 3.  
Keyword
 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 367 AA 
Protein Sequence
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 60
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 120
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE 180
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 240
NLLNMAYGVK RFSPIAIDGM SGLAGVGLSG GAAGAGWCIF VYNLSPEADE SVLWQLFGPF 300
GAVTNVKVIR DFTTNKCKGF GFVTMTNYDE AAMAIASLNG YRLGERVLQV SFKTSKQHKA 360 
Gene Ontology
 GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW. 
Interpro
 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS
 PR00961; HUDSXLRNA.