CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042447
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Transcription factor Sp3 
Protein Synonyms/Alias
  
Gene Name
 SP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
525DQQHQEGKRLRRVACubiquitination[1, 2, 3]
538ACTCPNCKEGGGRGTubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 713 AA 
Protein Sequence
IGPPSPGDDE EEAAAAAGAP AAAGATGDLA SAQLGGAPNR WEVLSATPTT IKDEAGNLVQ 60
IPSAATSSGQ YVLPLQNLQN QQIFSVAPGS DSSNGTVSSV QYQVIPQIQS ADGQQVQIGF 120
TGSSDNGGIN QESSQIQIIP GSNQTLLASG TPSANIQNLI PQTGQVQVQG VAIGGSSFPG 180
QTQVVANVPL GLPGNITFVP INSVDLDSLG LSGSSQTMTA GINADGHLIN TGQAMDSSDN 240
SERTGERVSP DINETNTDTD LFVPTSSSSQ LPVTIDSTGI LQQNTNSLTT SSGQVHSSDL 300
QGNYIQSPVS EETQAQNIQV STAQPVVQHL QLQESQQPTS QAQIVQGITP QTIHGVQASG 360
QNISQQALQN LQLQLNPGTF LIQAQTVTPS GQVTWQTFQV QGVQNLQNLQ IQNTAAQQIT 420
LTPVQTLTLG QVAAGGAFTS TPVSLSTGQL PNLQTVTVNS IDSAGIQLHP GENADSPADI 480
RIKEEEPDPE EWQLSGDSTL NTNDLTHLRV QVVDEEGDQQ HQEGKRLRRV ACTCPNCKEG 540
GGRGTNLGKK KQHICHIPGC GKVYGKTSHL RAHLRWHSGE RPFVCNWMYC GKRFTRSDEL 600
QRHRRTHTGE KKFVCPECSK RFMRSDHLAK HIKTHQNKKG IHSSSTVLAS VEAARDDTLI 660
TAGGTTLILA NIQQGSVSGI GTVNTSATSN QDILTNTEIP LQLVTVSGNE TME 713 
Gene Ontology
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0000987; F:core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030183; P:B cell differentiation; IEA:Compara.
 GO:0060216; P:definitive hemopoiesis; IEA:Compara.
 GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Compara.
 GO:0001892; P:embryonic placenta development; IEA:Compara.
 GO:0060136; P:embryonic process involved in female pregnancy; IEA:Compara.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0043353; P:enucleate erythrocyte differentiation; IEA:Compara.
 GO:0030851; P:granulocyte differentiation; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0030219; P:megakaryocyte differentiation; IEA:Compara.
 GO:0030224; P:monocyte differentiation; IEA:Compara.
 GO:0001779; P:natural killer cell differentiation; IEA:Compara.
 GO:0001503; P:ossification; IEA:Compara.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0001829; P:trophectodermal cell differentiation; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS