CPLM-020946

Genbank Nucleotide ID

Phosphoglycerate mutase 1

Protein Synonyms/Alias

BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B

Mus musculus (Mouse)

Position	Peptide	Type	References
5	***MAAYKLVLIRHG	acetylation	[1, 2]
5	***MAAYKLVLIRHG	ubiquitination	[3]
39	PAGHEEAKRGGQALR	acetylation	[1, 4]
100	GGLTGLNKAETAAKH	acetylation	[5]
106	NKAETAAKHGEAQVK	acetylation	[2]
106	NKAETAAKHGEAQVK	ubiquitination	[3]
113	KHGEAQVKIWRRSYD	acetylation	[1, 4]
113	KHGEAQVKIWRRSYD	ubiquitination	[3]
138	PFYSNISKDRRYADL	ubiquitination	[3]
157	LPSCESLKDTIARAL	acetylation	[1, 6]
157	LPSCESLKDTIARAL	ubiquitination	[3]
176	EEIVPQIKEGKRVLI	acetylation	[1, 4]
176	EEIVPQIKEGKRVLI	ubiquitination	[3]
225	YELDKNLKPIKPMQF	acetylation	[1, 5]
228	DKNLKPIKPMQFLGD	acetylation	[1]
251	EAVAAQGKVKK****	acetylation	[2]
251	EAVAAQGKVKK****	succinylation	[2]
251	EAVAAQGKVKK****	ubiquitination	[3]

[1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[5] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
[6] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]

Functional Description

Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

ACT_SITE 11 11 Tele-phosphohistidine intermediate (By
ACT_SITE 186 186 By similarity.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 14 14 Phosphoserine.
MOD_RES 26 26 Phosphotyrosine.
MOD_RES 31 31 Phosphoserine (By similarity).
MOD_RES 92 92 Phosphotyrosine (By similarity).
MOD_RES 118 118 Phosphoserine.
MOD_RES 251 251 N6-acetyllysine (By similarity).
MOD_RES 253 253 N6-acetyllysine (By similarity).
MOD_RES 254 254 N6-acetyllysine (By similarity).

Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Hydrolase; Isomerase; Phosphoprotein; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005634; C:nucleus; IEA:Compara.
GO:0004083; F:bisphosphoglycerate 2-phosphatase activity; IEA:EC.
GO:0004082; F:bisphosphoglycerate mutase activity; IEA:EC.
GO:0004619; F:phosphoglycerate mutase activity; IDA:MGI.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.

IPR013078; His_Pase_superF_clade-1.
IPR001345; PG/BPGM_mutase_AS.
IPR005952; Phosphogly_mut1.