CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039695
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 V-type proton ATPase subunit d 1 
Protein Synonyms/Alias
  
Gene Name
 ATP6V0D1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24EGLVRGLKAGVLSQAubiquitination[1]
77IDDRLKEKMVVEFRHubiquitination[2]
280LSKEDRAKLFPHCGRubiquitination[2, 3]
306ADDYEQVKNVADYYPubiquitination[1, 2, 4, 5, 6, 7]
316ADYYPEYKLLFEGAGubiquitination[1, 2, 4, 5, 7]
329AGSNPGDKTLEDRFFubiquitination[2, 4, 5]
341RFFEHEVKLNKLAFLubiquitination[2]
384IAQRHRAKIDNYIPIubiquitination[2, 3, 5, 6, 7]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 392 AA 
Protein Sequence
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ STDYGNFLAN 60
EASPLTVSVI DDRLKEKMVV EFRHMRNHAY EPLASFLDFI TQESEAGTPE GPGNMPKLGS 120
RPSPGHRPPF LRVSLLPWPP SSYSYMIDNV ILLITGTLHQ RSIAELVPKC HPLGSFEQME 180
AVNIAQTPAE LYNAILVDTP LAAFFQDCIS EQDLDEMNIE IIRNTLYKAY LESFYKFCTL 240
LGGTTADAMC PILEFEADRR AFIITINSFG TELSKEDRAK LFPHCGRLYP EGLAQLARAD 300
DYEQVKNVAD YYPEYKLLFE GAGSNPGDKT LEDRFFEHEV KLNKLAFLNQ FHFGVFYAFV 360
KLKEQECRNI VWIAECIAQR HRAKIDNYIP IF 392 
Gene Ontology
 GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. 
Interpro
 IPR002843; ATPase_V0-cplx_csu/dsu.
 IPR016727; ATPase_V0-cplx_dsu. 
Pfam
 PF01992; vATP-synt_AC39 
SMART
  
PROSITE
  
PRINTS