CPLM-005853

Genbank Nucleotide ID

High affinity immunoglobulin epsilon receptor subunit gamma

Protein Synonyms/Alias

Fc receptor gamma-chain; FcRgamma; Fc-epsilon RI-gamma; IgE Fc receptor subunit gamma; FceRI gamma

Homo sapiens (Human)

Position	Peptide	Type	References
60	AAITSYEKSDGVYTG	ubiquitination	[1, 2]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin.

DOMAIN 54 82 ITAM.
MOD_RES 65 65 Phosphotyrosine (By similarity).
MOD_RES 76 76 Phosphotyrosine (By similarity).
MOD_RES 78 78 Phosphothreonine (By similarity).
DISULFID 25 25 Interchain (By similarity).

Cell membrane; Complete proteome; Disulfide bond; IgE-binding protein; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0009897; C:external side of plasma membrane; IEA:Compara.
GO:0032998; C:Fc-epsilon receptor I complex; IEA:Compara.
GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0019767; F:IgE receptor activity; IEA:Compara.
GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IEA:Compara.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:Compara.
GO:0042742; P:defense response to bacterium; IEA:Compara.
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IEA:Compara.
GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
GO:0007229; P:integrin-mediated signaling pathway; IEA:Compara.
GO:0050900; P:leukocyte migration; TAS:Reactome.
GO:0045576; P:mast cell activation; IEA:Compara.
GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Compara.
GO:0002283; P:neutrophil activation involved in immune response; IEA:Compara.
GO:0030593; P:neutrophil chemotaxis; IEA:Compara.
GO:0006911; P:phagocytosis, engulfment; IEA:Compara.
GO:0030168; P:platelet activation; TAS:Reactome.
GO:0032733; P:positive regulation of interleukin-10 production; IEA:Compara.
GO:0032755; P:positive regulation of interleukin-6 production; IEA:Compara.
GO:0032765; P:positive regulation of mast cell cytokine production; IEA:Compara.
GO:0043306; P:positive regulation of mast cell degranulation; IEA:Compara.
GO:0050766; P:positive regulation of phagocytosis; IEA:Compara.
GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Compara.
GO:0001812; P:positive regulation of type I hypersensitivity; IEA:Compara.
GO:0001798; P:positive regulation of type IIa hypersensitivity; IEA:Compara.
GO:0001805; P:positive regulation of type III hypersensitivity; IEA:Compara.
GO:0010543; P:regulation of platelet activation; IEA:Compara.
GO:0002554; P:serotonin secretion by platelet; IEA:Compara.

IPR021663; CR3_zeta/IgE_Fc_rcpt_gamma.
IPR003110; Phos_immunorcpt_sig_ITAM.

PF02189; ITAM
PF11628; TCR_zetazeta