CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010712
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integral membrane protein DGCR2/IDD 
Protein Synonyms/Alias
  
Gene Name
 DGCR2 
Gene Synonyms/Alias
 IDD; KIAA0163 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
179PERSFGWKDQRKLWVubiquitination[1]
260HAESCYEKSSFLCKRacetylation[2]
266EKSSFLCKRSQTCVDacetylation[2]
266EKSSFLCKRSQTCVDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. 
Sequence Annotation
 DOMAIN 28 68 LDL-receptor class A.
 DOMAIN 115 241 C-type lectin.
 DOMAIN 270 333 VWFC.
 CARBOHYD 149 149 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 DISULFID 30 44 By similarity.
 DISULFID 37 57 By similarity.
 DISULFID 51 66 By similarity.
 DISULFID 145 265 By similarity.
 DISULFID 233 257 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Lectin; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MVPKADSGAF LLLFLLVLTV TEPLRPELRC NPGQFACRSG TIQCIPLPWQ CDGWATCEDE 60
SDEANCPEVT GEVRPHHGKE AVDPRQGRAR GGDPSHFHAV NVAQPVRFSS FLGKCPTGWH 120
HYEGTASCYR VYLSGENYWD AAQTCQRLNG SLATFSTDQE LRFVLAQEWD QPERSFGWKD 180
QRKLWVGYQY VITGRNRSLE GRWEVAFKGS SEVFLPPDPI FASAMSENDN VFCAQLQCFH 240
FPTLRHHDLH SWHAESCYEK SSFLCKRSQT CVDIKDNVVD EGFYFTPKGD DPCLSCTCHG 300
GEPEMCVAAL CERPQGCQQY RKDPKECCKF MCLDPDGNSL FDSMASGMRL VVSCISSFLI 360
LSLLLFMVHR LRQRRRERIE SLIGANLHHF NLGRRIPGFD YGPDGFGTGL TPLHLSDDGE 420
GGTFHFHDPP PPYTAYKYPD IGQPDDPPPP YEASIHPDSV FYDPADDDAF EPVEVSLPAP 480
GDGGSEGALL RRLEQPLPTA GASLADLEDS ADSSSALLVP PDPAQSGSTP AAEALPGGGR 540
HSRSSLNTVV 550 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc. 
Interpro
 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR001007; VWF_C. 
Pfam
 PF00057; Ldl_recept_a 
SMART
 SM00034; CLECT
 SM00192; LDLa
 SM00214; VWC 
PROSITE
 PS50041; C_TYPE_LECTIN_2
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS01208; VWFC_1
 PS50184; VWFC_2 
PRINTS