UniProt Accession

 CNPY2_MOUSE; Q9QXT0; Q3UBH8 

Genbank Protein ID

 AF186115; AK007914; AK013014; AK013568; AK019927; AK150953; BC008261 

Genbank Nucleotide ID

 AAF01433.1; BAB25346.1; BAB28597.1; BAB28909.1; BAB31921.1; BAE29986.1; AAH08261.1 

Protein Name

 Protein canopy homolog 2 

Protein Synonyms/Alias

 MIR-interacting saposin-like protein; Putative secreted protein ZSIG9; Transmembrane protein 4 

Gene Name

 Cnpy2 

Gene Synonyms/Alias

 Msap; Tmem4; Zsig9 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
49	IARVDPKKTIQMGSF	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity). 

Sequence Annotation

 DOMAIN 24 175 Saposin B-type.
 MOTIF 179 182 Prevents secretion from ER (Potential).
 DISULFID 28 171 By similarity.
 DISULFID 31 164 By similarity.
 DISULFID 86 137 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Endoplasmic reticulum; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.
 GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; IMP:BHF-UCL.
 GO:0010988; P:regulation of low-density lipoprotein particle clearance; IMP:BHF-UCL. 

Interpro

 IPR021852; DUF3456.
 IPR008139; SaposinB. 

Pfam

 PF11938; DUF3456 

SMART

  

PROSITE

 PS00014; ER_TARGET
 PS50015; SAP_B 

PRINTS