| Tag | Content |
|---|
| CPLM ID | CPLM-014309 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Type I iodothyronine deiodinase |
Protein Synonyms/Alias | 5DI; DIOI; Type 1 DI; Type-I 5'-deiodinase |
Gene Name | Dio1 |
Gene Synonyms/Alias | Itdi1; Txdi1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | SILAMGQKTGMARNP | ubiquitination | [1] | | 229 | GRICYKGKAGPWNYN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). |
Sequence Annotation | ACT_SITE 126 126 |
Keyword | Complete proteome; Endoplasmic reticulum; Membrane; Oxidoreductase; Reference proteome; Selenocysteine; Thyroid hormones biosynthesis; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 257 AA |
Protein Sequence | MGLPQLWLWL KRLVIFLQVA LEVAVGKVLM TLFPGRVKQS ILAMGQKTGM ARNPRFAPDN 60
WVPTFFSIQY FWFVLKVRWQ RLEDRAEFGG LAPNCTVVCL SGQKCNIWDF IQGSRPLVLN 120
FGSCTUPSFL LKFDQFKRLV DDFASTADFL IIYIEEAHAT DGWAFKNNVD IRQHRSLQER 180
VRAARLLLAR SPQCPVVVDT MQNQSSQLYA ALPERLYVIQ EGRICYKGKA GPWNYNPEEV 240
RAVLEKLCTP PRHVPQL 257 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0008430; F:selenium binding; IDA:MGI. GO:0004800; F:thyroxine 5'-deiodinase activity; IDA:UniProtKB. GO:0042446; P:hormone biosynthetic process; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |