UniProt Accession

 EAPP_HUMAN; Q56P03; Q9BVF4; Q9NWV5; Q9NZ86 

Genbank Protein ID

 AY157300; AY157301; AY869694; AF217512; AK000585; AL445363; BC001245 

Genbank Nucleotide ID

 AAO17041.1; AAO17042.1; AAX63200.1; AAF67623.1; BAA91271.1; AAH01245.1 

Protein Name

 E2F-associated phosphoprotein 

Protein Synonyms/Alias

 EAPP 

Gene Name

 EAPP 

Gene Synonyms/Alias

 C14orf11; BM-036 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	TMKTMEDKLSSLGTG	ubiquitination	[1]
93	GSSSGNGKVATAPTR	ubiquitination	[1, 2, 3]
143	ELLYDPEKDNRDQAW	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 109 109 Phosphoserine.
 MOD_RES 111 111 Phosphoserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0034244; P:negative regulation of transcription elongation from RNA polymerase II promoter; IDA:MGI.
 GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
 GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:MGI. 

Interpro

 IPR019370; E2F-assoc_phosphoprotein. 

Pfam

 PF10238; Eapp_C 

SMART

  

PROSITE

  

PRINTS