CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004644
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bone morphogenetic protein 7 
Protein Synonyms/Alias
 BMP-7; Osteogenic protein 1; OP-1; Eptotermin alfa 
Gene Name
 BMP7 
Gene Synonyms/Alias
 OP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
162EFRFDLSKIPEGEAVubiquitination[1]
178AAEFRIYKDYIRERFubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. 
Sequence Annotation
 CARBOHYD 187 187 N-linked (GlcNAc...) (Potential).
 CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 372 372 N-linked (GlcNAc...) (Potential).
 DISULFID 330 396
 DISULFID 359 428
 DISULFID 363 430
 DISULFID 395 395 Interchain.  
Keyword
 3D-structure; Chondrogenesis; Complete proteome; Cytokine; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor; Osteogenesis; Pharmaceutical; Polymorphism; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 431 AA 
Protein Sequence
MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 60
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS 120
LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY 180
IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR 240
HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS 300
QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE 360
GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY 420
RNMVVRACGC H 431 
Gene Ontology
 GO:0005615; C:extracellular space; IDA:UniProtKB.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
 GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
 GO:0071456; P:cellular response to hypoxia; ISS:BHF-UCL.
 GO:0016358; P:dendrite development; TAS:BHF-UCL.
 GO:0048596; P:embryonic camera-type eye morphogenesis; IEA:Compara.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0009880; P:embryonic pattern specification; IEA:Compara.
 GO:0060272; P:embryonic skeletal joint morphogenesis; IEA:Compara.
 GO:0030855; P:epithelial cell differentiation; IEA:Compara.
 GO:0001837; P:epithelial to mesenchymal transition; TAS:HGNC.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0040007; P:growth; IEA:InterPro.
 GO:0001707; P:mesoderm formation; IEA:Compara.
 GO:0001823; P:mesonephros development; IEP:UniProtKB.
 GO:0072136; P:metanephric mesenchymal cell proliferation involved in metanephros development; IEA:Compara.
 GO:0072133; P:metanephric mesenchyme morphogenesis; IEA:Compara.
 GO:0001656; P:metanephros development; IEP:UniProtKB.
 GO:0070487; P:monocyte aggregation; IDA:UniProtKB.
 GO:0072125; P:negative regulation of glomerular mesangial cell proliferation; IDA:UniProtKB.
 GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0072040; P:negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; IEA:Compara.
 GO:0045839; P:negative regulation of mitosis; IDA:UniProtKB.
 GO:0050768; P:negative regulation of neurogenesis; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; ISS:BHF-UCL.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.
 GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Compara.
 GO:0060686; P:negative regulation of prostatic bud formation; IEA:Compara.
 GO:0010664; P:negative regulation of striated muscle cell apoptotic process; ISS:BHF-UCL.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0072134; P:nephrogenic mesenchyme morphogenesis; IEA:Compara.
 GO:0048812; P:neuron projection morphogenesis; IDA:MGI.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0001503; P:ossification; IEA:UniProtKB-KW.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0030501; P:positive regulation of bone mineralization; IDA:BHF-UCL.
 GO:1900006; P:positive regulation of dendrite development; IDA:BHF-UCL.
 GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:UniProtKB.
 GO:1900106; P:positive regulation of hyaluranon cable assembly; IDA:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IDA:BHF-UCL.
 GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
 GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0034504; P:protein localization to nucleus; IDA:UniProtKB.
 GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IEA:Compara.
 GO:2000121; P:regulation of removal of superoxide radicals; ISS:BHF-UCL.
 GO:0001501; P:skeletal system development; TAS:ProtInc.
 GO:0060395; P:SMAD protein signal transduction; IDA:UniProtKB.
 GO:0043401; P:steroid hormone mediated signaling pathway; IMP:UniProtKB.
 GO:0001657; P:ureteric bud development; ISS:UniProtKB. 
Interpro
 IPR001839; TGF-b_C.
 IPR001111; TGF-b_N.
 IPR015615; TGF-beta-rel.
 IPR017948; TGFb_CS. 
Pfam
 PF00019; TGF_beta
 PF00688; TGFb_propeptide 
SMART
 SM00204; TGFB 
PROSITE
 PS00250; TGF_BETA_1
 PS51362; TGF_BETA_2 
PRINTS