UniProt Accession

 CNTN1_RAT; Q63198 

Genbank Protein ID

 D38492 

Genbank Nucleotide ID

 BAA07504.1 

Protein Name

 Contactin-1 

Protein Synonyms/Alias

 Neural cell surface protein F3 

Gene Name

 Cntn1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
955	PDGQHDGKLFSTHKH	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. 

Sequence Annotation

 DOMAIN 41 131 Ig-like C2-type 1.
 DOMAIN 137 223 Ig-like C2-type 2.
 DOMAIN 241 326 Ig-like C2-type 3.
 DOMAIN 331 407 Ig-like C2-type 4.
 DOMAIN 413 500 Ig-like C2-type 5.
 DOMAIN 504 603 Ig-like C2-type 6.
 DOMAIN 605 701 Fibronectin type-III 1.
 DOMAIN 708 805 Fibronectin type-III 2.
 DOMAIN 810 901 Fibronectin type-III 3.
 DOMAIN 906 998 Fibronectin type-III 4.
 LIPID 1001 1001 GPI-anchor amidated serine (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 CARBOHYD 258 258 N-linked (GlcNAc...) (Potential).
 CARBOHYD 338 338 N-linked (GlcNAc...) (Potential).
 CARBOHYD 457 457 N-linked (GlcNAc...) (Potential).
 CARBOHYD 473 473 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).
 CARBOHYD 521 521 N-linked (GlcNAc...) (Potential).
 CARBOHYD 593 593 N-linked (GlcNAc...) (Potential).
 CARBOHYD 935 935 N-linked (GlcNAc...) (Potential).
 DISULFID 65 114 By similarity.
 DISULFID 158 211 By similarity.
 DISULFID 263 310 By similarity.
 DISULFID 352 391 By similarity.
 DISULFID 436 484 By similarity.
 DISULFID 526 585 By similarity.  

Keyword

 Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Notch signaling pathway; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1021 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0030246; F:carbohydrate binding; IEA:Compara.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0021549; P:cerebellum development; IEA:Compara.
 GO:0031175; P:neuron projection development; IEA:Compara.
 GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2. 

Pfam

 PF00041; fn3
 PF07679; I-set 

SMART

 SM00060; FN3
 SM00409; IG
 SM00408; IGc2 

PROSITE

 PS50853; FN3
 PS50835; IG_LIKE 

PRINTS