CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinesin-like protein KIF21A 
Protein Synonyms/Alias
  
Gene Name
 KIF21A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
327HVPYRDSKLTRLLQDubiquitination[1]
1051FLSMGINKGLQAAQKubiquitination[2]
1058KGLQAAQKEAQIKVLubiquitination[2, 3]
1063AQKEAQIKVLEGRLKacetylation[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Microtubule; Motor protein; Nucleotide-binding; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1675 AA 
Protein Sequence
MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 60
QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 120
LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 180
STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 240
PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 300
LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 360
TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 420
MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 480
SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 540
AKKDLEKLKR KEKRKKKRLQ KLEESNREER SVAGKEDNTD TDQEKKEEKG VSERENNELE 600
VEESQEVSDH EDEEEEEEEE EDDIDGGESS DESDSESDEK ANYQADLANI TCEIAIKQKL 660
IDELENSQKR LQTLKKQYEE KLMMLQHKIR DTQLERDQVL QNLGSVESYS EEKAKKVRSE 720
YEKKLQAMNK ELQRLQAAQK EHARLLKNQS QYEKQLKKLQ QDVMEMKKTK VRLMKQMKEE 780
QEKARLTESR RNREIAQLKK DQRKRDHQLR LLEAQKRNQE VVLRRKTEEV TALRRQVRPM 840
SDKVAGKVTR KLSSSDAPAQ DTGSSAAAVE TDASRTGAQQ KMRIPVARVQ ALPTPATNGN 900
RKKYQRKGLT GRVFISKTAR MKWQLLERRV TDIIMQKMTI SNMEADMNRL LKQREELTKR 960
REKLSKRREK IVKENGEGDK NVANINEEME SLTANIDYIN DSISDCQANI MQMEEAKEEG 1020
ETLDVTAVIN ACTLTEARYL LDHFLSMGIN KGLQAAQKEA QIKVLEGRLK QTEITSATQN 1080
QLLFHMLKEK AELNPELDAL LGHALQDFKH FFVENVEDST DEDAPLNSPG SEGSTLSSDL 1140
MKLCGEVKPK NKARRRTTTQ MELLYADSSE LASDTSTGDA SLPGPLTPVA EGQEIGMNTE 1200
TSGTSAREKE LSPPPGLPSK IGSISRQSSL SEKKIPEPSP VTRRKAYEKA EKSKAKEQKH 1260
SDSGTSEASL SPPSSPPSRP RNELNVFNRL TVSQGNTSVQ QDKSDESDSS LSEVHRNSNL 1320
RGIINPFPAS KGIRAFPLQC IHIAEGHTKA VLCVDSTDDL LFTGSKDRTC KVWNLVTGQE 1380
IMSLGGHPNN VVSVKYCNYT SLVFTVSTSY IKVWDIRDSA KCIRTLTSSG QVTLGDACSA 1440
STSRTVAIPS GENQINQIAL NPTGTFLYAA SGNAVRMWDL KRFQSTGKLT GHLGPVMCLT 1500
VDQISSGQDL IITGSKDHYI KMFDVTEGAL GTVSPTHNFE PPHYDGIEAL TIQGDNLFSG 1560
SRDNGIKKWD LTQKDLLQQV PNAHKDWVCA LGVVPDHPVL LSGCRGGILK VWNMDTFMPV 1620
GEMKGHDSPI NAICVNSTHI FTAADDRTVR IWKARNLQDG QISDTGDLGE DIASN 1675 
Gene Ontology
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase.
 IPR009053; Prefoldin.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00225; Kinesin
 PF00400; WD40 
SMART
 SM00129; KISc
 SM00320; WD40 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00380; KINESINHEAVY.