UniProt Accession

 DCUP_HUMAN; P06132; A8K762; Q16863; Q16883; Q53YB8; Q53ZP6; Q6IB28; Q9BUZ0 

Genbank Protein ID

 M14016; X89267; AF047383; AF104421; AF104422; AF104423; AF104424; AF104425; AF104426; AF104427; AF104428; AF104429; AF104430; AF104431; AF104432; AF104433; AF104434; AF104435; AF104436; AF104437; AF104438; AF104439; AF104440; AY292986; BT006737; CR456976; CR542057; AK291877; AL359473; CH471059; BC001778; U30787; M60891 

Genbank Nucleotide ID

 AAA61258.1; CAA61540.1; AAC03563.1; AAD04571.1; AAD04572.1; AAD04573.1; AAD04574.1; AAD04575.1; AAD04576.1; AAD04577.1; AAD04578.1; AAD04579.1; AAD04580.1; AAD04581.1; AAD04582.1; AAD04583.1; AAD04584.1; AAD04585.1; AAD04586.1; AAD04587.1; AAD04588.1; AAD04589.1; AAD04590.1; AAP44118.1; AAP35383.1; CAG33257.1; CAG46854.1; BAF84566.1; CAI16440.1; EAX07007.1; AAH01778.1; AAC50482.1; AAB59456.1 

Protein Name

 Uroporphyrinogen decarboxylase 

Protein Synonyms/Alias

 UPD; URO-D 

Gene Name

 UROD 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
15	PQGFPELKNDTFLRA	ubiquitination	[1]
297	KARECVGKTVTLQGN	ubiquitination	[1, 2]
359	AFVDAVHKHSRLLRQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. 

Sequence Annotation

 REGION 37 41 Substrate binding.
 BINDING 55 55 Substrate.
 BINDING 85 85 Substrate.
 BINDING 86 86 Substrate.
 BINDING 164 164 Substrate.
 BINDING 219 219 Substrate.
 BINDING 339 339 Substrate.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 61 61 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Decarboxylase; Direct protein sequencing; Disease mutation; Heme biosynthesis; Lyase; Phosphoprotein; Porphyrin biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004853; F:uroporphyrinogen decarboxylase activity; IDA:UniProtKB.
 GO:0006783; P:heme biosynthetic process; IC:UniProtKB.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR006361; Uroporphyrinogen_deCO2ase_HemE.
 IPR000257; Uroporphyrinogen_deCOase. 

Pfam

 PF01208; URO-D 

SMART

  

PROSITE

 PS00906; UROD_1
 PS00907; UROD_2 

PRINTS