CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015282
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup98-Nup96 
Protein Synonyms/Alias
 Nuclear pore complex protein Nup98; 98 kDa nucleoporin; Nucleoporin Nup98; Nup98; Nuclear pore complex protein Nup96; 96 kDa nucleoporin; Nucleoporin Nup96; Nup96 
Gene Name
 Nup98 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
193HQCITAMKEYESKSLacetylation[1]
639ERFSFLSKPVDENNQubiquitination[2]
665FYTNPIAKPIPQTPEubiquitination[2]
818VGEGLNRKAEVTLDGubiquitination[2]
1018RFGHIPSKGETVQEIubiquitination[2]
1199PFKVHLEKLGLRQRKubiquitination[2]
1206KLGLRQRKLDEDLQLubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC (By similarity). 
Sequence Annotation
 DOMAIN 738 880 Peptidase S59.
 REGION 1 156 FG repeats 1.
 REGION 157 213 GLEBS; interaction with RAE1 (By
 REGION 214 480 FG repeats 2.
 MOD_RES 524 524 Phosphoserine (By similarity).
 MOD_RES 603 603 N6-acetyllysine (By similarity).
 MOD_RES 608 608 Phosphoserine (By similarity).
 MOD_RES 612 612 Phosphoserine (By similarity).
 MOD_RES 618 618 Phosphoserine (By similarity).
 MOD_RES 623 623 Phosphoserine (By similarity).
 MOD_RES 625 625 Phosphoserine (By similarity).
 MOD_RES 670 670 Phosphothreonine (By similarity).
 MOD_RES 673 673 Phosphoserine (By similarity).
 MOD_RES 681 681 Phosphoserine (By similarity).
 MOD_RES 839 839 Phosphoserine (By similarity).
 MOD_RES 888 888 Phosphoserine (By similarity).
 MOD_RES 934 934 Phosphoserine (By similarity).
 MOD_RES 1027 1027 Phosphoserine (By similarity).
 MOD_RES 1042 1042 Phosphoserine (By similarity).
 MOD_RES 1059 1059 Phosphoserine (By similarity).
 MOD_RES 1069 1069 Phosphothreonine (By similarity).  
Keyword
 3D-structure; Acetylation; Autocatalytic cleavage; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1816 AA 
Protein Sequence
MFNKSFGTPF GGSTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG 60
GLFGTSSFSQ PATSTSTGFG FGTSTGTSNS LFGTASTGTS LFSSQNNAFA QNKPTGFGNF 120
GTSTSSGGLF GTTNTTSNPF GSTSGSLFGP SSFTAAPTGT TIKFNPPTGT DTMVKAGVST 180
NISTKHQCIT AMKEYESKSL EELRLEDYQA NRKGPQNQVG GGTTAGLFGS SPATSSATGL 240
FSSSTTNSAF SYGQNKTAFG TSTTGFGTNP GGLFGQQNQQ TTSLFSKPFG QATTTPNTGF 300
SFGNTSTLGQ PSTNTMGLFG VTQASQPGGL FGTATNTSTG TAFGTGTGLF GQPNTGFGAV 360
GSTLFGNNKL TTFGTSTTSA PSFGTTSGGL FGNKPTLTLG TNTNTSNFGF GTNNSGSSIF 420
GSKPAAGTLG TGLGTGFGTA LGAGQASLFG NNQPKIGGPL GTGAFGAPGF NTSTAILGFG 480
APQAPVALTD PNASAAQQAV LQQHLNSLTY SPFGDSPLFR NPMSDPKKKE ERLKPTNPAA 540
QKALTTPTHY KLTPRPATRV RPKALQTTGT AKSHLFDGLD DDEPSLANGA FMPKKSIKKL 600
VLKNLNNSNL FSPVNHDSED LASPSEYPEN GERFSFLSKP VDENNQQDGE DDSLVSRFYT 660
NPIAKPIPQT PESVGNKNNS SSNVEDTIVA LNMRAALRNG LEGSSEETSF HDESLQDDRE 720
EIENNAYHIH PAGIVLTKVG YYTIPSMDDL AKITNEKGEC IVSDFTIGRK GYGSIYFEGD 780
VNLTNLNLDD IVHIRRKEVI VYVDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP 840
DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF SKYGLQDSDE EEEEHPPKTT 900
SKKLKTAPLP PAGQATTFQM TLNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVPD 960
SVLEESVPED QEPVSASTHI ASSLGINPHV LQIMKASLLV DEEDVDAMDQ RFGHIPSKGE 1020
TVQEICSPRL PISASHSSKS RSIVGGLLQS KFASGTFLSP SASVQECRTP RTSSRMNIPS 1080
TSPWSVPLPL ATVFTVPSPA PEVQLKTVGI RRQPGLVPLE KSITYGKGKL LMDMALFMGR 1140
SFRVGWGPNW TLANSGEQLH GSHELENHQV ADSMEYGFLP NPVAVKSLSE SPFKVHLEKL 1200
GLRQRKLDED LQLYQTPLEL KLKHSTVHVD ELCPLIVPNP GVSVIHDYAD WVKDSPGDFL 1260
ELPIVKHWSL TWTLCEALWG HLKELDGQLD EPSEYIQTLE RRRAFSRWLS HTAAPQIEEE 1320
VSLTRRDSPV EAVFSYLTGS RISGACCLAQ QSGDHRLALL LSQLVGSQSV RELLTMQLAD 1380
WHQLQADSFI HDERLRIFAL LAGKPVWQLS EQKQINVCSQ LDWKRTLAIH LWYLLPPTAS 1440
ISRALSMYEE AFQNTPEGDK YACSPLPSYL EGCGCMVEEE KDSRRPLQDV CFHLLKLYSD 1500
RHYELNQLLE PRSITADPLD YRLSWHLWEV LRALNYTHLS EQCEGVLQAS YAGQLESEGL 1560
WEWAIFVFLH IDNSGMREKA VRELLTRHCQ LSETPESWAK EAFLTQKLCV PAEWIHEAKA 1620
VRAHMESNKH LEALYLFKAG HWNRCHKLVI RHLASDAIIN ENYDYLKGFL EDLAPPERSS 1680
LIQDWETSGL VYLDYIRVIE MLHRIQQVDC SGYELEHLHT KVTSLCNRIE QIPCYNAKDR 1740
LAQSDMAKRV ANLLRVVLSL QHAPDATSNS TPDPQRVPLR LLAPHIGRLP MPEDYALEEL 1800
RGLTQSYLRE LTVGSQ 1816 
Gene Ontology
 GO:0000776; C:kinetochore; IEA:Compara.
 GO:0042405; C:nuclear inclusion body; IEA:Compara.
 GO:0031965; C:nuclear membrane; ISS:UniProtKB.
 GO:0034399; C:nuclear periphery; IEA:Compara.
 GO:0044615; C:nuclear pore nuclear basket; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0017056; F:structural constituent of nuclear pore; IEA:Compara.
 GO:0006260; P:DNA replication; IEA:Compara.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; IEA:Compara.
 GO:0000059; P:protein import into nucleus, docking; IEA:Compara. 
Interpro
 IPR021967; Nup96.
 IPR007230; Peptidase_S59. 
Pfam
 PF04096; Nucleoporin2
 PF12110; Nup96 
SMART
  
PROSITE
 PS51434; NUP_C 
PRINTS