UniProt Accession

 PRVA_MOUSE; P32848 

Genbank Protein ID

 X54613; X59382; BC027424; S75909; S75910 

Genbank Nucleotide ID

 CAA38434.1; CAA42025.1; AAH27424.1; AAB33066.1 

Protein Name

 Parvalbumin alpha 

Protein Synonyms/Alias

  

Gene Name

 Pvalb 

Gene Synonyms/Alias

 Pva 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
14	LSAEDIKKAIGAFAA	ubiquitination	[1]
28	AADSFDHKKFFQMVG	acetylation	[2]
28	AADSFDHKKFFQMVG	ubiquitination	[1]
29	ADSFDHKKFFQMVGL	acetylation	[2]
29	ADSFDHKKFFQMVGL	ubiquitination	[1]
37	FFQMVGLKKKNPDEV	acetylation	[2]
37	FFQMVGLKKKNPDEV	ubiquitination	[1]
46	KNPDEVKKVFHILDK	ubiquitination	[1]
53	KVFHILDKDKSGFIE	acetylation	[2]
53	KVFHILDKDKSGFIE	ubiquitination	[1]
55	FHILDKDKSGFIEED	acetylation	[2]
55	FHILDKDKSGFIEED	ubiquitination	[1]
69	DELGSILKGFSSDAR	acetylation	[2]
69	DELGSILKGFSSDAR	ubiquitination	[1]
81	DARDLSAKETKTLLA	ubiquitination	[1]
84	DLSAKETKTLLAAGD	ubiquitination	[1]
92	TLLAAGDKDGDGKIG	ubiquitination	[1]
97	GDKDGDGKIGVEEFS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. 

Sequence Annotation

 DOMAIN 39 74 EF-hand 1.
 DOMAIN 78 110 EF-hand 2.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 73 73 Phosphoserine.
 MOD_RES 79 79 Phosphoserine.
 MOD_RES 83 83 Phosphothreonine.  

Keyword

 Acetylation; Calcium; Complete proteome; Direct protein sequencing; Metal-binding; Muscle protein; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 

Interpro

 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR008080; Parvalbumin. 

Pfam

 PF13499; EF_hand_5 

SMART

 SM00054; EFh 

PROSITE

 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 

PRINTS