| Tag | Content |
|---|
| CPLM ID | CPLM-001442 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Roundabout homolog 1 |
Protein Synonyms/Alias | |
Gene Name | Robo1 |
Gene Synonyms/Alias | Dutt1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 898 | STYAGIRKVPSFTFT | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). May be required for lung development. |
Sequence Annotation | DOMAIN 29 125 Ig-like C2-type 1.
DOMAIN 131 218 Ig-like C2-type 2.
DOMAIN 223 307 Ig-like C2-type 3.
DOMAIN 312 407 Ig-like C2-type 4.
DOMAIN 416 502 Ig-like C2-type 5.
DOMAIN 522 607 Fibronectin type-III 1.
DOMAIN 634 724 Fibronectin type-III 2.
DOMAIN 736 825 Fibronectin type-III 3.
MOD_RES 901 901 Phosphoserine (By similarity).
MOD_RES 999 999 Phosphotyrosine (By similarity).
MOD_RES 1016 1016 Phosphoserine (By similarity).
MOD_RES 1034 1034 Phosphotyrosine (By similarity).
MOD_RES 1075 1075 Phosphotyrosine (By similarity).
MOD_RES 1201 1201 Phosphothreonine (By similarity).
MOD_RES 1258 1258 Phosphoserine (By similarity).
CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
CARBOHYD 424 424 N-linked (GlcNAc...) (Potential).
CARBOHYD 751 751 N-linked (GlcNAc...) (Potential).
CARBOHYD 781 781 N-linked (GlcNAc...) (Potential).
CARBOHYD 788 788 N-linked (GlcNAc...) (Potential).
DISULFID 50 108 Potential.
DISULFID 152 201 Potential.
DISULFID 244 291 Potential.
DISULFID 333 389 Potential.
DISULFID 437 486 Potential. |
Keyword | Chemotaxis; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Neurogenesis; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1612 AA |
Protein Sequence | MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 60
EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYICVA RNYLGEAVSH 120
NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 180
IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 240
EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 300
EASATLTVQE PPHFVVKPRD QVVALGRTVT FQCEATGNPQ PAIFWRREGS QNLLFSYQPP 360
QSSSRFSVSQ TGDLTITNVQ RSDVGYYICQ TLNVAGSIIT KAYLEVTDVI ADRPPPVIRQ 420
GPVNQTVAVD GTLILSCVAT GSPAPTILWR KDGVLVSTQD SRIKQLESGV LQIRYAKLGD 480
TGRYTCTAST PSGEATWSAY IEVQEFGVPV QPPRPTDPNL IPSAPSKPEV TDVSKNTVTL 540
SWQPNLNSGA TPTSYIIEAF SHASGSSWQT AAENVKTETF AIKGLKPNAI YLFLVRAANA 600
YGISDPSQIS DPVKTQDVPP TSQGVDHKQV QRELGNVVLH LHNPTILSSS SVEVHWTVDQ 660
QSQYIQGYKI LYRPSGASHG ESEWLVFEVR TPTKNSVVIP DLRKGVNYEI KARPFFNEFQ 720
GADSEIKFAK TLEEAPSAPP RSVTVSKNDG NGTAILVTWQ PPPEDTQNGM VQEYKVWCLG 780
NETKYHINKT VDGSTFSVVI PSLVPGIRYS VEVAASTGAG PGVKSEPQFI QLDSHGNPVS 840
PEDQVSLAQQ ISDVVRQPAF IAGIGAACWI ILMVFSIWLY RHRKKRNGLT STYAGIRKVP 900
SFTFTPTVTY QRGGEAVSSG GRPGLLNISE PATQPWLADT WPNTGNNHND CSINCCTAGN 960
GNSDSNLTTY SRPADCIANY NNQLDNKQTN LMLPESTVYG DVDLSNKINE MKTFNSPNLK 1020
DGRFVNPSGQ PTPYATTQLI QANLSNNMNN GAGDSSEKHW KPPGQQKPEV APIQYNIMEQ 1080
NKLNKDYRAN DTIPPTIPYN QSYDQNTGGS YNSSDRGSST SGSQGHKKGA RTPKAPKQGG 1140
MNWADLLPPP PAHPPPHSNS EEYNMSVDES YDQEMPCPVP PAPMYLQQDE LQEEEDERGP 1200
TPPVRGAASS PAAVSYSHQS TATLTPSPQE ELQPMLQDCP EDLGHMPHPP DRRRQPVSPP 1260
PPPRPISPPH TYGYISGPLV SDMDTDAPEE EEDEADMEVA KMQTRRLLLR GLEQTPASSV 1320
GDLESSVTGS MINGWGSASE EDNISSGRSS VSSSDGSFFT DADFAQAVAA AAEYAGLKVA 1380
RRQMQDAAGR RHFHASQCPR PTSPVSTDSN MSAVVIQKAR PAKKQKHQPG HLRREAYADD 1440
LPPPPVPPPA IKSPTVQSKA QLEVRPVMVP KLASIEARTD RSSDRKGGSY KGREALDGRQ 1500
VTDLRTNPSD PREAQEQPND GKGRGTRQPK RDLPPAKTHL GQEDILPYCR PTFPTSNNPR 1560
DPSSSSSMSS RGSGSRQREQ ANVGRRNMAE MQVLGGFERG DENNEELEET ES 1612 |
Gene Ontology | GO:0030673; C:axolemma; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016199; P:axon midline choice point recognition; IGI:UniProtKB. GO:0060763; P:mammary duct terminal end bud growth; IMP:MGI. GO:0008285; P:negative regulation of cell proliferation; IMP:MGI. GO:0021891; P:olfactory bulb interneuron development; IGI:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |