CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017238
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arf-GAP domain and FG repeat-containing protein 1 
Protein Synonyms/Alias
 HIV-1 Rev-binding protein homolog; Nucleoporin-like protein RIP 
Gene Name
 Agfg1 
Gene Synonyms/Alias
 Hrb; Rip 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
114FRDPQKVKEFLQEKYubiquitination[1]
175APALHLNKGTPSQSPacetylation[2]
175APALHLNKGTPSQSPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
 Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. 
Sequence Annotation
 DOMAIN 11 135 Arf-GAP.
 ZN_FING 29 52 C4-type.
 MOD_RES 177 177 Phosphothreonine.
 MOD_RES 179 179 Phosphoserine.
 MOD_RES 181 181 Phosphoserine.
 CARBOHYD 367 367 O-linked (GlcNAc) (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Developmental protein; Differentiation; DNA-binding; Glycoprotein; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Spermatogenesis; Transport; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 561 AA 
Protein Sequence
MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN 60
PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK 120
YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGESAPA LHLNKGTPSQ 180
SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AAQNSANADF 240
ANFDAFGQSS GSSNFGGFPT ASHSSFQPQT TGGSAGSVNA NFAHFDNFPK SSSADFGTFS 300
TSQSHQTAST VSKVSTNKAG LQTADKYAAL ANLDNIFSAG QGGDQGSGFG TTGKAPVGSV 360
VSVPSHSSAS SDKYAALAEL DSVFSSAATS SNAYTPTSNA SSSVFGTVPV GASAQTQPAS 420
SGPAPFGATP STNPFVAATG PSAASSTNPF QTNARGATAA TFGTASMSMP AGFGTPAQYS 480
LPTSFSGSFQ QPAFPAQAAF PQQTAFSQQP NGAGFATFGQ TKPVVTPFGQ VAAAGVSSNP 540
FMTGAPTGQL PTGSSSTNPF L 561 
Gene Ontology
 GO:0042995; C:cell projection; IDA:MGI.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0043025; C:neuronal cell body; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0001675; P:acrosome assembly; IMP:MGI.
 GO:0045109; P:intermediate filament organization; IMP:MGI.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
 GO:0007289; P:spermatid nucleus differentiation; IMP:MGI.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 
Interpro
 IPR001164; ArfGAP. 
Pfam
 PF01412; ArfGap 
SMART
 SM00105; ArfGap 
PROSITE
 PS50115; ARFGAP 
PRINTS
 PR00405; REVINTRACTNG.