CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033910
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Elongation factor 1-delta 
Protein Synonyms/Alias
  
Gene Name
 Eef1d 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10TNFLAHEKIWFDKFKacetylation[1]
10TNFLAHEKIWFDKFKubiquitination[2]
15HEKIWFDKFKYDDAEacetylation[1]
59RARENIQKSLAGSSGubiquitination[2]
107DLQQAISKLEARLSSacetylation[1, 3]
107DLQQAISKLEARLSSubiquitination[2]
117ARLSSLEKSSPTPRAacetylation[1, 4]
117ARLSSLEKSSPTPRAsuccinylation[4]
117ARLSSLEKSSPTPRAubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 194 AA 
Protein Sequence
MATNFLAHEK IWFDKFKYDD AERRFYEQMN GPVTSGSRQE NGASVILRDI ARARENIQKS 60
LAGSSGPGAS SGPGGDHSEL IVRITSLEVE NQNLRGVVQD LQQAISKLEA RLSSLEKSSP 120
TPRATAPQTQ HVSPMRQVEP PTKKGATPAE DDEDKDIDLF GSDEEEEDKE AARLREERLR 180
QYAEKKAKKP TLVA 194 
Gene Ontology
 GO:0005853; C:eukaryotic translation elongation factor 1 complex; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:Compara.
 GO:0003746; F:translation elongation factor activity; IEA:InterPro.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEA:Compara. 
Interpro
 IPR018940; EF-1_beta_acid_region_euk.
 IPR001326; Transl_elong_EF1B_B/D_CS. 
Pfam
 PF10587; EF-1_beta_acid 
SMART
  
PROSITE
 PS00824; EF1BD_1 
PRINTS